References

“Memorandum of Understanding on Copper Mitigation in Watersheds and Waterways between U.S. Environmental Protection Agency and Motor & Equipment Manufacturers Association, Automotive Aftermarket Suppliers Association, Brake Manufacturers Council and Heavy Duty Manufacturers Association and Auto Care Association and Alliance of Automobile Manufacturers and Association of Global Automakers, Inc. and Truck and Engine Manufacturers Association and Environmental Council of the States.” 2015. Preprint. https://www.epa.gov/npdes/memorandum-understanding-copper-mitigation-watershed-and-waterways.

ASTM International. 2023. ASTM-D5666 | Standard Test Method for Rubber Chemical Antidegradants; Purity of p-Phenylenediamine (PPD) Antidegradants by High Performance Liquid Chromatography . ASTM-D5666-95R23. https://www.document-center.com/standards/show/ASTM-D5666.

AcuTread. 2017. “Tire Wear | AcuTread Tire Service | Retreading Manufacturers.” AcuTread , February 28. https://acutread.com/resources/post/factors-influence-tire-wear/.

Al Shoyaib, Abdullah, Sabrina Rahman Archie, and Vardan T. Karamyan. 2019. “Intraperitoneal Route of Drug Administration: Should It Be Used in Experimental Animal Studies?” Pharmaceutical Research 37 (1): 12. https://doi.org/10.1007/s11095-019-2745-x.

Allen, Jonathan O., Olga Alexandrova, and Kamil E. Kaloush. 2006. Tire Wear Emissions for Asphalt Rubber and Portland Cement Concrete Pavement Surfaces . Arizona State University. https://azdot.gov/sites/default/files/2019/05/tire-wear-emissions-for-asphalt-rubber-portland-cement-concrete-April2006.pdf.

Antonczak, Brittany, Tammy M. Thompson, Mindi W. DePaola, and Gregory Rowangould. 2023. “2020 Near-Roadway Population Census, Traffic Exposure and Equity in the United States.” Transportation Research Part D: Transport and Environment 125 (December): 103965. https://doi.org/10.1016/j.trd.2023.103965.

Armada, Daniel, Antia Martinez-Fernandez, Maria Celeiro, Thierry Dagnac, and Maria Llompart. 2023. “Assessment of the Bioaccessibility of PAHs and Other Hazardous Compounds Present in Recycled Tire Rubber Employed in Synthetic Football Fields.” Science of the Total Environment 857: 159485. https://doi.org/10.1016/j.scitotenv.2022.159485.

Armada, Daniel, Maria Celeiro, Thierry Dagnac, and Maria Llompart. 2022. “Green Methodology Based on Active Air Sampling Followed by Solid Phase Microextraction and Gas Chromatography-Tandem Mass Spectrometry Analysis to Determine Hazardous Substances in Different Environments Related to Tire Rubber.” Journal of Chromatography A 1668: 462911. https://doi.org/10.1016/j.chroma.2022.462911.

Arnold, J. G., R. Srinivasan, R. S. Muttiah, and J. R. Williams. 1998. “Large Area Hydrologic Modeling and Assessment Part I: Model Development1.” JAWRA Journal of the American Water Resources Association 34 (1): 73–89. https://doi.org/10.1111/j.1752-1688.1998.tb05961.x.

Baensch-Baltruschat, Beate, Birgit Kocher, Friederike Stock, and Georg Reifferscheid. 2020. “Tyre and Road Wear Particles (TRWP)—A Review of Generation, Properties, Emissions, Human Health Risk, Ecotoxicity, and Fate in the Environment.” Science of the Total Environment 733 (September): 137823. https://doi.org/10.1016/j.scitotenv.2020.137823.

Baldauf, R., E. Thoma, A. Khlystov, et al. 2008. “Impacts of Noise Barriers on Near-Road Air Quality.” Atmospheric Environment 42 (32): 7502–7. https://doi.org/10.1016/j.atmosenv.2008.05.051.

Baldauf, Richard W. 2016. Recommendations for Constructing Roadside Vegetation Barriers to Improve Near-Road Air Quality . No. 321772. https://cfpub.epa.gov/si/si_public_record_report.cfm?Lab=NRMRL&dirEntryId=321772&simpleSearch=1&searchAll=Recommendations+for+constructing+roadside+vegetation+barriers+to+improve+near+road+air+quality.

Baldauf, Richard W. 2017. “Roadside Vegetation Design Characteristics That Can Improve Local, near-Road Air Quality.” Transportation Research Part D: Transport and Environment 52: 354–61. https://doi.org/10.1016/j.trd.2017.03.013.

Baldauf, Richard W., Vlad Isakov, Parikshit Deshmukh, Akula Venkatram, Bo Yang, and K. Max Zhang. 2016. “Influence of Solid Noise Barriers on Near-Road and on-Road Air Quality.” Atmospheric Environment 129: 265–76. https://doi.org/10.1016/j.atmosenv.2016.01.025.

Benis, Khaled Zoroufchi, Ali Behnami, Shahab Minaei, Markus Brinkmann, Kerry N. McPhedran, and Jafar Soltan. 2023. “Environmental Occurrence and Toxicity of 6PPD Quinone, an Emerging Tire Rubber–Derived Chemical: A Review.” Environmental Science & Technology Letters , ahead of print, September 1. World. https://doi.org/10.1021/acs.estlett.3c00521.

Blair, Stephanie I., Clyde H. Barlow, and Jenifer K. McIntyre. 2021. “Acute Cerebrovascular Effects in Juvenile Coho Salmon Exposed to Roadway Runoff.” Canadian Journal of Fisheries and Aquatic Sciences , ahead of print, February. 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7. https://doi.org/10.1139/cjfas-2020-0240.

Botelho, Marina Tenório, Gabriely Groto Militão, Markus Brinkmann, and Gisela de Aragão Umbuzeiro. 2023. “Toxicity and Mutagenicity Studies of 6PPD-Quinone in a Marine Invertebrate Species and Bacteria.” Environmental and Molecular Mutagenesis 64 (6): 335–41. https://doi.org/10.1002/em.22560.

Boucher, Julien, and Damien Friot. 2017. Primary Microplastics in the Oceans: A Global Evaluation of Sources . IUCN.

Brinkmann, Markus, David Montgomery, Summer Selinger, et al. 2022. “Acute Toxicity of the Tire Rubber–Derived Chemical 6PPD-Quinone to Four Fishes of Commercial, Cultural, and Ecological Importance.” Environmental Science & Technology Letters , March 2, acs.estlett.2c00050. https://doi.org/10.1021/acs.estlett.2c00050.

CalRecycle. 2023. “California Tire Derived Products Catalog.” https://www.e-productcatalog.com/TDPCatalog/.

Calarnou, Laurie, Mounir Traïkia, Martin Leremboure, et al. 2023. “Assessing Biodegradation of Roadway Particles via Complementary Mass Spectrometry and NMR Analyses.” Science of the Total Environment 900 (November): 165698. https://doi.org/10.1016/j.scitotenv.2023.165698.

California Department of Fish and Wildlife. n.d. Biogeographic Information and Observation System (BIOS) . V. v5.99.22. Accessed April 9, 2019. https://apps.wildlife.ca.gov/bios/.

Cao, Guodong, Jing Zhang, Wei Wang, Pengfei Wu, Yi Ru, and Zongwei Cai. 2022. “Mass Spectrometry Analysis of a Ubiquitous Tire Rubber–Derived Quinone in the Environment.” TrAC Trends in Analytical Chemistry , 116756. https://doi.org/10.1016/j.trac.2022.116756.

Cao, Guodong, Wei Wang, Jing Zhang, et al. 2022. “New Evidence of Rubber-Derived Quinones in Water, Air, and Soil.” Environmental Science & Technology 56 (7): 4142–50. https://doi.org/10.1021/acs.est.1c07376.

Cao, Guodong, Wei Wang, Jing Zhang, et al. 2023. “Occurrence and Fate of Substituted P-Phenylenediamine-Derived Quinones in Hong Kong Wastewater Treatment Plants.” Environmental Science & Technology , ahead of print, October 5. https://doi.org/10.1021/acs.est.3c03758.

Carey, Andrea, Alex Gipe, William Hobbs, and Sandra O’Neill. 2023. Investigating the Source of PBDE Contaminant Exposure in Steelhead Trout within the Major Tributaries of the Nisqually River Basin . Final Contract Report Submitted to the Nisqually Indian Tribe WDFW Report Number FPT 23-02. Washington Department of Fish and Wildlife — Toxics Biological Observation System (TBiOS) and Washington Department of Ecology — Environmental Assessment Program. https://wdfw.wa.gov/sites/default/files/publications/02440/wdfw02440.pdf.

Carlucci, Giovanni, Luisa Airoldi, Roberto Fanelli, and Biagio Laguzzi. 1984. “Quantitative Analysis of Aromatic Amines in Human Urine by Gas Chromatography—Mass Spectrometry—Selected-Ion Monitoring.” Journal of Chromatography B: Biomedical Sciences and Applications 311: 141–47. https://www.sciencedirect.com/science/article/abs/pii/S0378434700847003.

Castan, Stephanie, Anya Sherman, Ruoting Peng, et al. 2023. “Uptake, Metabolism, and Accumulation of Tire Wear Particle–Derived Compounds in Lettuce.” Environmental Science & Technology 57 (1): 168–78. https://doi.org/10.1021/acs.est.2c05660.

Cataldo, Franco, Brad Faucette, Semone Huang, and Warren Ebenezer. 2015. “On the Early Reaction Stages of Ozone with N,N′-Substituted p-Phenylenediamines (6PPD, 77PD) and N,N′,N″-Substituted-1,3,5-Triazine ‘Durazone®’: An Electron Spin Resonance (ESR) and Electronic Absorption Spectroscopy Study.” Polymer Degradation and Stability 111 (January): 223–31. https://doi.org/10.1016/j.polymdegradstab.2014.11.011.

Center for Sustainable Systems, University of Michigan. 2023. “Personal Transportation Factsheet.” Center for Sustainable Systems, July. https://css.umich.edu/publications/factsheets/mobility/personal-transportation-factsheet.

Challis, J. K., H. Popick, S. Prajapati, et al. 2021. “Occurrences of Tire Rubber–Derived Contaminants in Cold-Climate Urban Runoff.” Environmental Science & Technology Letters 8 (11): 961–67. https://doi.org/10.1021/acs.estlett.1c00682.

Chasar, DW, and R. W. Layer. 2010. “Basic Rubber Compounding.” In The Vanderbilt Rubber Handbook , 14th ed. M.F. Sheridan (Ed.). R.T. Vanderbilt Company.

Chen, Xiaoli, Tao He, Xinlu Yang, et al. 2023. “Analysis, Environmental Occurrence, Fate and Potential Toxicity of Tire Wear Compounds 6PPD and 6PPD-Quinone.” Journal of Hazardous Materials 452 (June): 131245. https://doi.org/10.1016/j.jhazmat.2023.131245.

Chow, Michelle I., Jessica I. Lundin, Chelsea J. Mitchell, et al. 2019. “An Urban Stormwater Runoff Mortality Syndrome in Juvenile Coho Salmon.” Aquatic Toxicology 214 (September): 105231. https://doi.org/10.1016/j.aquatox.2019.105231.

Cormier, Susan M., and Glenn W. Suter. 2008. “A Framework for Fully Integrating Environmental Assessment.” Environmental Management 42 (4): 543–56. https://doi.org/10.1007/s00267-008-9138-y.

Cunningham, W. L., and C. W. Schalk. 2011. Groundwater Technical Procedures of the U.S. Geological Survey: U.S. Geological Survey Techniques and Methods 1–A1 . https://pubs.usgs.gov/tm/1a1/.

DTSC. 2021. DTSC Tribal Consultations and Meetings: Summary of Input on Motor Vehicle Tires Containing 6PPD . https://dtsc.ca.gov/wp-content/uploads/sites/31/2021/12/Summary-of-Tribal-Input-SCP-6PPD.pdf.

DTSC. 2022. Product-Chemical Profile for Motor Vehicle Tires Containing N-(1,3-Dimethylbutyl)-N′-Phenyl-p-Phenylenediamine (6PPD) from the California Department of Toxic Substances Control (DTSC) . https://dtsc.ca.gov/wp-content/uploads/sites/31/2022/05/6PPD-in-Tires-Priority-Product-Profile_FINAL-VERSION_accessible.pdf.

DTSC. 2022. The Impact of California’s Brake Pad Law: Report to the Legislature. Department of Toxic Substances Control and State Water Resources Control Board . https://dtsc.ca.gov/wp-content/uploads/sites/31/2023/08/Brake-Pad-Legislative-Report-Accessible.pdf.

Dahl, Andreas, Arash Gharibi, Erik Swietlicki, et al. 2006. “Traffic-Generated Emissions of Ultrafine Particles from Pavement–Tire Interface.” Atmospheric Environment 40 (7): 1314–23. https://doi.org/10.1016/j.atmosenv.2005.10.029.

Deng, Chengliang, Jialing Huang, Yunqing Qi, Da Chen, and Wei Huang. 2022. “Distribution Patterns of Rubber Tire–Related Chemicals with Particle Size in Road and Indoor Parking Lot Dust.” Science of the Total Environment 844: 157144. https://doi.org/10.1016/j.scitotenv.2022.157144.

Dennis, Nicole M., Audrey J. Braun, and Jay Gan. 2024. “A High-Throughput Analytical Method for Complex Contaminant Mixtures in Biosolids.” Environmental Pollution 345: 123517. https://doi.org/10.1016/j.envpol.2024.123517.

Deshmukh, Parikshit, Vlad Isakov, Akula Venkatram, et al. 2019. “The Effects of Roadside Vegetation Characteristics on Local, near-Road Air Quality.” Air Quality, Atmosphere, & Health 12 (March): 259–70. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339705/.

Di, Shanshan, Zhenzhen Liu, Huiyu Zhao, et al. 2022. “Chiral Perspective Evaluations: Enantioselective Hydrolysis of 6PPD and 6PPD-Quinone in Water and Enantioselective Toxicity to Gobiocypris Rarus and Oncorhynchus Mykiss .” Environment International 166 (August): 107374. https://doi.org/10.1016/j.envint.2022.107374.

Du, Bibai, Bowen Liang, Yi Li, Mingjie Shen, Liang-Ying Liu, and Lixi Zeng. 2022. “First Report on the Occurrence of N -(1,3-Dimethylbutyl)- N′ -Phenyl- p -Phenylenediamine (6PPD) and 6PPD-Quinone as Pervasive Pollutants in Human Urine from South China.” Environmental Science & Technology Letters , ahead of print, November 21. World. https://doi.org/10.1021/acs.estlett.2c00821.

Du, Bowen, Jonathan M. Lofton, Katherine T. Peter, et al. 2017. “Development of Suspect and Non-Target Screening Methods for Detection of Organic Contaminants in Highway Runoff and Fish Tissue with High-Resolution Time-of-Flight Mass Spectrometry.” Environmental Science: Processes & Impacts 19 (9): 1185–96. https://doi.org/10.1039/C7EM00243B.

ECHA. 2021. “Substance Infocard: N-1,3-Dimethylbutyl-N’-Phenyl-p-Phenylenediamine. European Chemicals Agency (ECHA).” April 7. https://echa.europa.eu/substance-information/-/substanceinfo/100.011.222.

ECHA. 2022. “6PPD: 1,4-Benzenediamine, N1-(1,3-Dimethylbutyl)-N4-Phenyl- Registration Dossier - European Chemicals Agency (ECHA).” Preprint, December 2. https://echa.europa.eu/registration-dossier/-/registered-dossier/15367/1/2.

Earthjustice. 2023. “U.S. Fishing Groups Sue Tire Manufacturers Over 6PPD Impacts on Salmon, Steelhead.” Earthjustice. https://earthjustice.org/press/2023/u-s-fishing-groups-sue-tire-manufacturers-over-6ppd-impacts-on-salmon-steelhead.

Eastern Brook Trout Venture. 2024. “Eastern Brook Trout Health Map (Trout Unlimited).” https://easternbrooktrout.org/science-data/ebtjv-maps/copy_of_EBTJV%20Map%206_09_11.jpg/image_view_fullscreen.

Ettinger, A. K., E. R. Buhle, B. E. Feist, et al. 2021. “Prioritizing Conservation Actions in Urbanizing Landscapes.” Scientific Reports 11 (1): 818. https://doi.org/10.1038/s41598-020-79258-2.

Eurofins. 2023. Research Summary for the Single-Laboratory Validation Study of a Draft EPA LC-MS-MS Isotope Dilution Method for 6PPD-Quinone . https://www.epa.gov/system/files/documents/2024-01/final-research-summary-6ppd-q-11-30-23.pdf.

Fang, Chanlin, Liya Fang, Shanshan Di, et al. 2022. “Not yet Peer Reviewed: Bioaccumulation of N-(1,3-Dimethylbutyl)-N′-Phenyl-p-Phenylenediamine (6PPD) and Its Potential Cardiotoxicity in Larval Zebrafish (Danio Rerio).” SSRN Scholarly Paper No. 4166691. Rochester, NY, July 19. https://papers.ssrn.com/abstract=4166691.

Fang, Chanlin, Liya Fang, Shanshan Di, et al. 2023. “Characterization of N-(1,3-Dimethylbutyl)- N′ -Phenyl- p -Phenylenediamine (6PPD)-Induced Cardiotoxicity in Larval Zebrafish ( Danio Rerio ).” Science of the Total Environment 882 (July): 163595. https://doi.org/10.1016/j.scitotenv.2023.163595.

Fang, Jiacheng, Xiaoxiao Wang, Guodong Cao, et al. 2024. “6PPD-Quinone Exposure Induces Neuronal Mitochondrial Dysfunction to Exacerbate Lewy Neurites Formation Induced by α-Synuclein Preformed Fibrils Seeding.” Journal of Hazardous Materials 465 (March): 133312. https://doi.org/10.1016/j.jhazmat.2023.133312.

Fang, Liya, Chanlin Fang, Shanshan Di, et al. 2023. “Oral Exposure to Tire Rubber–Derived Contaminant 6PPD and 6PPD-Quinone Induce Hepatotoxicity in Mice.” Science of the Total Environment 869 (April): 161836. https://doi.org/10.1016/j.scitotenv.2023.161836.

Feißel, Toni, Miles Kunze, David Hesse, Valentin Ivanov, Klaus Augsburg, and Sebastian Gramstat. 2024. “On-Road Vehicle Measurement of Tire Wear Particle Emissions and Approach for Emission Prediction.” Tire Science and Technology 52 (1): 2–14. https://doi.org/10.2346/tire.22.21024.

Feist, Blake E., Eric R. Buhle, David H. Baldwin, et al. 2017. “Roads to Ruin: Conservation Threats to a Sentinel Species across an Urban Gradient.” Ecological Applications 27 (8): 2382–96. https://doi.org/https://doi.org/10.1002/eap.1615.

Field, R. D., and J. D. Reynolds. 2012. “Ecological Links between Salmon, Large Carnivore Predation, and Scavenging Birds.” Journal of Avian Biology 44: 9–16.

Flores, Mugdha. 2023. “Saving Washington’s Salmon from Toxic Tire Dust.” January. https://ecology.wa.gov/blog/january-2023/saving-washington-s-salmon-from-toxic-tire-dust.

Foldvik, Anders, Fedor Kryuchkov, Eva Ulvan, Roar Sandodden, and Elii Kvingedal. 2024. “Acute Toxicity Testing of Pink Salmon ( Oncorhynchus gorbuscha ) with the Tire Rubber–Derived Chemical 6PPD‐Quinone.” Environmental Toxicology and Chemistry , ahead of print. https://doi.org/https://doi.org/10.1002/etc.5875.

Foldvik, Anders, Fedor Kryuchkov, Roar Sandodden, and Silvio Uhlig. 2022. “Acute Toxicity Testing of the Tire Rubber–Derived Chemical 6PPD-Quinone on Atlantic Salmon ( Salmo Salar ) and Brown Trout ( Salmo Trutta ).” Environmental Toxicology and Chemistry 41 (12): 3041–45. https://doi.org/10.1002/etc.5487.

Foscari, Aurelio, Bettina Seiwert, Daniel Zahn, Matthias Schmidt, and Thorsten Reemtsma. 2024. “Leaching of Tire Particles and Simultaneous Biodegradation of Leachables.” Water Research 253 (April): 121322. https://doi.org/10.1016/j.watres.2024.121322.

Foscari, Aurelio, Natascha Schmidt, Bettina Seiwert, Dorte Herzke, Richard Sempéré, and Thorsten Reemtsma. 2023. “Leaching of Chemicals and DOC from Tire Particles under Simulated Marine Conditions.” Frontiers in Environmental Science 11 (June). https://doi.org/10.3389/fenvs.2023.1206449.

French, B. F., D. H. Baldwin, J. Cameron, et al. 2022. “Urban Roadway Runoff Is Lethal to Juvenile Coho, Steelhead, and Chinook Salmonids, But Not Congeneric Sockeye.” Environmental Science & Technology Letters 9 (9): 733–38. https://doi.org/10.1021/acs.estlett.2c00467.

Gaga, Eftade O., Tom Harner, Ewa Dabek-Zlotorzynska, et al. 2019. “Polyurethane Foam (PUF) Disk Samplers for Measuring Trace Metals in Ambient Air.” Environmental Science & Technology Letters 6 (9): 545–50. https://doi.org/10.1021/acs.estlett.9b00420.

Geosyntec Consultants, and Wright Water Engineers, Inc. 2009. Urban Stormwater BMP Performance Monitoring . https://static1.squarespace.com/static/5f8dbde10268ab224c895ad7/t/604926dae8a36b0ee128f8ac/1615406817379/2009MonitoringManualSingleFile.pdf.

Gilbert, C.E., B.D. Beck, and E.J. Calabrese. 1990. Ozone Risk Communication and Management . Taylor & Francis.

Gradient. 2024. Preliminary (Stage 1) Alternatives Analysis Report: Motor Vehicle Tires Containing N-(1,3-Dimethylbutyl)-N’-Phenyl-p-Phenylenediamine (6PPD) . https://www.ustires.org/sites/default/files/2024-03/USTMA%20Consortium%206PPD%20AA%20Preliminary%20Report_3-25-24.pdf.

Grasse, Nico, Bettina Seiwert, Riccardo Massei, Stefan Scholz, Qiuguo Fu, and Thorsten Reemtsma. 2023. “Uptake and Biotransformation of the Tire Rubber–Derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo ( Danio rerio ).” Environmental Science & Technology 57 (41): 15598–607. https://doi.org/10.1021/acs.est.3c02819.

Greenwald, Roby, Jeremy A. Sarnat, and Christina H. Fuller. 2024. “The Impact of Vegetative and Solid Roadway Barriers on Particulate Matter Concentration in Urban Settings.” PLOS ONE 19 (1): e0296885. https://doi.org/10.1371/journal.pone.0296885.

Greer, Justin B., Ellie M. Dalsky, Rachael F. Lane, and John D. Hansen. 2023. “Establishing an In Vitro Model to Assess the Toxicity of 6PPD-Quinone and Other Tire Wear Transformation Products.” Environmental Science & Technology Letters , ahead of print, May 2. https://doi.org/10.1021/acs.estlett.3c00196.

Greer, Justin B., Ellie M. Dalsky, Rachael F. Lane, and John D. Hansen. 2023. “Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon.” Environmental Science & Technology , ahead of print, July 19. https://doi.org/10.1021/acs.est.3c01040.

Grigoratos, Theodoros, and Giorgio Martini. 2014. Non-Exhaust Traffic Related Emissions. Brake and Tyre Wear PM . EUR 26648 EN. European Commission Joint Research Centre Institute of Energy and Transport.

Grigoratos, Theodoros, and Giorgio Martini. 2015. “Brake Wear Particle Emissions: A Review.” Environmental Science and Pollution Research 22 (4): 2491–504. https://doi.org/10.1007/s11356-014-3696-8.

Gulliver, J. S., A. J. Erickson, and P. T. Weiss, eds. 2010. Stormwater Treatment: Assessment and Maintenance . University of Minnesota, St. Anthony Falls Laboratory. Minneapolis, MN. https://stormwaterbook.safl.umn.edu/.

Hägg, Fanny, Dorte Herzke, Vladimir A. Nikiforov, et al. 2023. “Ingestion of Car Tire Crumb Rubber and Uptake of Associated Chemicals by Lumpfish (Cyclopterus Lumpus).” Frontiers in Environmental Science 11 (October): 1219248. https://doi.org/10.3389/fenvs.2023.1219248.

Ha, Jin U., Seok H. Bae, Yu J. Choi, et al. 2023. “Control of Tire Wear Particulate Matter through Tire Tread Prescription.” Polymers 15 (13): 2795. https://doi.org/10.3390/polym15132795.

Halama, Jonathan, Robert B. McKane, Bradley L. Barnhart, et al. 2024. “Watershed Analysis of Urban Stormwater Contaminant 6PPD-Quinone Hotspots and Stream Concentrations Using a Process-Based Ecohydrological Model.” Frontiers in Environmental Science 12 (March). https://doi.org/10.3389/fenvs.2024.1364673.

Halama, Jonathan, Robert McKane, Vivian Phan, et al. 2022. “VELMA Model Green Infrastructure Applications for Reducing 6PPD-Quinone Concentrations in Puget Sound Urban Stream.” EMCON 2021, March 25. https://www.ezview.wa.gov/Portals/_2001/Documents/Documents/HalamaMcKaneGISummitSalishSeaTalk25Mar2022_SWG30Mar2022_UpdateJJH.pdf.

Halle, Louise L., Annemette Palmqvist, Kristoffer Kampmann, and Farhan R. Khan. 2020. “Ecotoxicology of Micronized Tire Rubber: Past, Present and Future Considerations.” Science of The Total Environment 706 (March): 135694. https://doi.org/10.1016/j.scitotenv.2019.135694.

Harris, Douglas C. 2008. “The Boldt Decision in Canada: Aboriginal Treaty Rights to Fish on the Pacific, in Alexandra Harmon, Ed.” In The Power of Promises: Rethinking Indian Treaties In the Pacific Northwest . University of Washington Press. https://commons.allard.ubc.ca/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1179&context=fac_pubs.

He, Wenmiao, Aihua Gu, and Dayong Wang. 2023. “Four-Week Repeated Exposure to Tire-Derived 6-PPD Quinone Causes Multiple Organ Injury in Male BALB/c Mice.” Science of the Total Environment 894 (October): 164842. https://doi.org/10.1016/j.scitotenv.2023.164842.

Hiki, Kyoshiro, Kenta Asahina, Kota Kato, et al. 2021. “Acute Toxicity of a Tire Rubber–Derived Chemical, 6PPD Quinone, to Freshwater Fish and Crustacean Species.” Environmental Science & Technology Letters 8 (9): 779–84. https://doi.org/10.1021/acs.estlett.1c00453.

Hiki, Kyoshiro, and Hiroshi Yamamoto. 2022. “Concentration and Leachability of N-(1,3-Dimethylbutyl)- N′ -Phenyl- p- Phenylenediamine (6PPD) and Its Quinone Transformation Product (6PPD-Q) in Road Dust Collected in Tokyo, Japan.” Environmental Pollution 302 (June): 119082. https://doi.org/10.1016/j.envpol.2022.119082.

Hiki, Kyoshiro, and Hiroshi Yamamoto. 2022. “The Tire-Derived Chemical 6PPD-Quinone Is Lethally Toxic to the White-Spotted Char Salvelinus leucomaenis pluvius but Not to Two Other Salmonid Species.” Environmental Science & Technology Letters 9 (12): 1050–55. https://doi.org/10.1021/acs.estlett.2c00683.

Holtgrieve, G. W., and D. E. Schindler. 2011. “Marine-Derived Nutrients, Bioturbation, and Ecosystem Metabolism: Reconsidering the Role of Salmon in Streams.” Ecological Society of America 92: 375–85.

Holzer, Katie, and Torrey Lindbo. 2018. “Pervious Pavement Pollutant Study.” Lower Willamette River Toxics Reduction Meeting, January 31. https://gaftp.epa.gov/region10/columbiariver/WWTRP/Meeting-2018-01-31/gresham-pervious-pavement-pollutant-study.pdf.

Howie, Douglas, and Brandi Lubliner. 2024. Guidance on Using New High Performance Bioretention Soil Mixes . Washington State Department of Ecology, Water Quality Program. https://apps.ecology.wa.gov/publications/documents/2110023.pdf.

Hu, Ximin, Haoqi (Nina) Zhao, Zhenyu Tian, Katherine T. Peter, Michael C. Dodd, and Edward P. Kolodziej. 2023. “Chemical Characteristics, Leaching, and Stability of the Ubiquitous Tire Rubber–Derived Toxicant 6PPD-Quinone.” Environmental Science: Processes & Impacts 25 (5): 901–11. https://doi.org/10.1039/D3EM00047H.

Hu, Ximin, Haoqi Nina Zhao, Zhenyu Tian, Katherine T. Peter, Michael C. Dodd, and Edward P. Kolodziej. 2022. “Transformation Product Formation upon Heterogeneous Ozonation of the Tire Rubber Antioxidant 6PPD ( N -(1,3-Dimethylbutyl)- N′ -Phenyl- p- Phenylenediamine).” Environmental Science & Technology Letters , ahead of print, April 12. https://doi.org/10.1021/acs.estlett.2c00187.

Hua, Xin, Xiao Feng, Geyu Liang, Jie Chao, and Dayong Wang. 2023. “Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans .” Environmental Science & Technology , ahead of print, March 13. https://doi.org/10.1021/acs.est.2c08644.

Hua, Xin, Xiao Feng, Geyu Liang, Jie Chao, and Dayong Wang. 2023. “Long-Term Exposure to 6-PPD Quinone Reduces Reproductive Capacity by Enhancing Germline Apoptosis Associated with Activation of Both DNA Damage and Cell Corpse Engulfment in Caenorhabditis elegans .” Journal of Hazardous Materials 454 (July): 131495. https://doi.org/10.1016/j.jhazmat.2023.131495.

Hua, Xin, and Dayong Wang. 2023. “Tire-Rubber Related Pollutant 6-PPD Quinone: A Review of Its Transformation, Environmental Distribution, Bioavailability, and Toxicity.” Journal of Hazardous Materials 459: 132265. https://doi.org/10.1016/j.jhazmat.2023.132265.

Huang, Wei, Yumeng Shi, Jialing Huang, et al. 2021. “Occurrence of Substituted p -Phenylenediamine Antioxidants in Dusts.” Environmental Science & Technology Letters 8 (5): 381–85. https://doi.org/10.1021/acs.estlett.1c00148.

Hunt, Kathy, Ralph Hindle, and Tarun Anumol. 2021. Quantitation of Toxic Tire Degradant 6PPD-Quinone in Surface Water . Application Note: Environmental. Agilent Technologies, Inc.

Huntink, N.M., and Datta, R.N. 2003. “A Novel Slow Release Antidegradant for the Rubber Industry—Part 1: Migration Behavior of Newly Developed Anti-Ozonant Compared to Conventional Antidegradants.” Kautschuk Gummi Kunststoffe 56 (6): 310–15.

Hur, Jin, Soobin Yim, and Mark A. Schlautman. 2003. “Copper Leaching from Brake Wear Debris in Standard Extraction Solutions. Electronic Supplementary Information (ESI) Available: Thermodynamic Equilibrium Speciation Results from the Geochemical Model MINTEQ. See Http://Www.Rsc.Org/Suppdata/Em/B3/B303820c/.” Journal of Environmental Monitoring 5 (5): 837. https://doi.org/10.1039/b303820c.

Hyatt, K.D., and Godbout, L. 2000. “A Review of Salmon as Keystone Species and Their Utility as Critical Indicators of Regional Biodiversity and Ecosystem Integrity.” L. M. Darling, Editor. Proceedings of a Conference on the Biology and Management of Species and Habitats at Risk, Kamloops, B.C.,  15–19 Feb., 1999 (Victoria, B.C.) Two: 520. https://www.env.gov.bc.ca/wld/documents/fr02hyatt2.pdf.

ITRC. 2014. “Contaminated Sediments Remediation: Remedy Selection for Contaminated Sediments.” August. https://clu-in.org/download/contaminantfocus/sediments/Sediment-ITRC-CS-2.pdf.

ITRC. 2018. “Stormwater Best Management Practices Performance Evaluation.” https://stormwater-1.itrcweb.org/.

ITRC. 2023. “Microplastics.” Preprint, Washington, D.C.: Interstate Technology & Regulatory Council, MP Team. https://mp-1.itrcweb.org.

Ikarashi, Yoshiaki, and Masa-aki Kaniwa. 2000. “Determination of P-Phenylenediamine and Related Antioxidants in Rubber Boots by High Performance Liquid Chromatography. Development of an Analytical Method for N-(1-Methylheptyl)-N’-Phenyl-p-Phenylenediamine.” Journal of Health Science 46 (6): 467–73. https://doi.org/10.1248/jhs.46.467.

Ji, Jiawen, Changsheng Li, Bingjie Zhang, et al. 2022. “Exploration of Emerging Environmental Pollutants 6PPD and 6PPDQ in Honey and Fish Samples.” Food Chemistry 396: 133640. https://doi.org/10.1016/j.foodchem.2022.133640.

Ji, Jiawen, Jinze Huang, Niannian Cao, et al. 2022. “Multiview Behavior and Neurotransmitter Analysis of Zebrafish Dyskinesia Induced by 6PPD and Its Metabolites.” Science of The Total Environment 838: 156013. https://doi.org/10.1016/j.scitotenv.2022.156013.

Jin, Ruihe, Yan Wu, Qun He, et al. 2023. “Ubiquity of Amino Accelerators and Antioxidants in Road Dust from Multiple Land Types: Targeted and Nontargeted Analysis.” Environmental Science & Technology 57 (28): 10361–72. https://doi.org/10.1021/acs.est.3c01448.

Johannessen, Cassandra, Amandeep Saini, Xianming Zhang, and Tom Harner. 2022. “Air Monitoring of Tire-Derived Chemicals in Global Megacities Using Passive Samplers.” Environmental Pollution 314 (December): 120206. https://doi.org/10.1016/j.envpol.2022.120206.

Johannessen, Cassandra, John Liggio, Xianming Zhang, Amandeep Saini, and Tom Harner. 2022. “Composition and Transformation Chemistry of Tire-Wear Derived Organic Chemicals and Implications for Air Pollution.” Atmospheric Pollution Research 13 (9): 101533. https://doi.org/10.1016/j.apr.2022.101533.

Johannessen, Cassandra, Paul Helm, Brent Lashuk, Viviane Yargeau, and Chris D. Metcalfe. 2022. “The Tire Wear Compounds 6PPD-Quinone and 1,3-Diphenylguanidine in an Urban Watershed.” Archives of Environmental Contamination and Toxicology 82 (2): 171–79. https://doi.org/10.1007/s00244-021-00878-4.

Johannessen, Cassandra, Paul Helm, and Chris D. Metcalfe. 2021. “Detection of Selected Tire Wear Compounds in Urban Receiving Waters.” Environmental Pollution 287 (October): 117659. https://doi.org/10.1016/j.envpol.2021.117659.

Johannessen, Cassandra, and Chris D. Metcalfe. 2022. “The Occurrence of Tire Wear Compounds and Their Transformation Products in Municipal Wastewater and Drinking Water Treatment Plants.” Environmental Monitoring and Assessment 194 (10): 731. https://doi.org/10.1007/s10661-022-10450-9.

Kahl, Michael D., Daniel L. Villeneuve, Kyle Stevens, et al. 2014. “An Inexpensive, Temporally Integrated System for Monitoring Occurrence and Biological Effects of Aquatic Contaminants in the Field: Novel System for in Situ Testing.” Environmental Toxicology and Chemistry 33 (7): 1584–95. https://doi.org/10.1002/etc.2591.

Kendra, Will, and Roger Willms. 1990. Recurrent Coho Salmon Mortality at Maritime Heritage Fish Hatchery, Bellingham: A Synthesis of Data Collected from 1987–1989. Washington State Department of Ecology, Environmental Services Program, Surface Water Investigations Section. https://apps.ecology.wa.gov/publications/documents/90e54.pdf.

Klöckner, Philipp, Bettina Seiwert, Paul Eisentraut, Ulrike Braun, Thorsten Reemtsma, and Stephan Wagner. 2020. “Characterization of Tire and Road Wear Particles from Road Runoff Indicates Highly Dynamic Particle Properties.” Water Research 185 (October): 116262. https://doi.org/10.1016/j.watres.2020.116262.

Klöckner, Philipp, Bettina Seiwert, Steffen Weyrauch, Beate I. Escher, Thorsten Reemtsma, and Stephan Wagner. 2021. “Comprehensive Characterization of Tire and Road Wear Particles in Highway Tunnel Road Dust by Use of Size and Density Fractionation.” Chemosphere , ahead of print. https://doi.org/https://doi.org/10.1016/j.chemosphere.2021.130530.

Klöckner, Philipp, Bettina Seiwert, Stephan Wagner, and Thorsten Reemtsma. 2021. “Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates.” Environmental Science & Technology 55 (17): 11723–32. https://doi.org/10.1021/acs.est.1c02723.

Klauschies, Toni, and Jana Isanta-Navarro. 2022. “The Joint Effects of Salt and 6PPD Contamination on a Freshwater Herbivore.” Science of the Total Environment 829: 154675. https://doi.org/10.1016/j.scitotenv.2022.154675.

Klun, Barbara, Ula Rozman, and Gabriela Kalčíková. 2023. “Environmental Aging and Biodegradation of Tire Wear Microplastics in the Aquatic Environment.” Journal of Environmental Chemical Engineering 11 (5): 110604. https://doi.org/10.1016/j.jece.2023.110604.

Kole, Pieter Jan, Ansje J. Löhr, Frank G. A. J. Van Belleghem, and Ad M. J. Ragas. 2017. “Wear and Tear of Tyres: A Stealthy Source of Microplastics in the Environment.” International Journal of Environmental Research and Public Health 14 (10): 1265. https://doi.org/10.3390/ijerph14101265.

Kreider, Marisa L., Julie M. Panko, Britt L. McAtee, Leonard I. Sweet, and Brent L. Finley. 2010. “Physical and Chemical Characterization of Tire-Related Particles: Comparison of Particles Generated Using Different Methodologies.” Science of the Total Environment 408 (3): 652–59. https://doi.org/10.1016/j.scitotenv.2009.10.016.

Kuczkowski, J. A. 1990. “Effects of Ozone on Tires and the Control of These Effects.” In Ozone Risk Communication and Management , Gilbert, C. E., Beck, B. D., Calabrese, E. J. (eds.). Taylor & Francis.

Kuczkowski, J.A. 1989. “The Inhibition of Oxidative and Ozonic Processes in Elastomers.” In Oxidation Inhibition in Organic Materials , J. Pospisil and P.P Klemchuk (eds.). Taylor & Francis. https://books.google.com/books?id=HEOnh9bgu0IC.

Kuraishi, Takashi, Kenji Takizawa, and Tayfun E. Tezduyar. 2019. “Tire Aerodynamics with Actual Tire Geometry, Road Contact and Tire Deformation.” Computational Mechanics 63 (6): 1165–85. https://doi.org/10.1007/s00466-018-1642-1.

Lane, Rachael F., Kelly L. Smalling, Paul M. Bradley, et al. 2024. “Tire-Derived Contaminants 6PPD and 6PPD-Q: Analysis, Sample Handling, and Reconnaissance of United States Stream Exposures.” Chemosphere , July 11, 142830. https://doi.org/10.1016/j.chemosphere.2024.142830.

Larson, Chad A., Glenn Merritt, Jack Janisch, et al. 2019. “The First Statewide Stream Macroinvertebrate Bioassessment in Washington State with a Relative Risk and Attributable Risk Analysis for Multiple Stressors.” Ecological Indicators 102 (July): 175–85. https://doi.org/10.1016/j.ecolind.2019.02.032.

Lattimer, R. P., E. R. Hooser, R. W. Layer, and C. K. Rhee. 1983. “Mechanisms of Ozonation of N-(1,3-Dimethylbutyl)-N′-Phenyl-p-Phenylenediamine.” Rubber Chemistry and Technology 56 (2): 431–39. https://doi.org/10.5254/1.3538136.

Levin, Phillip S., Emily R. Howe, and James C. Robertson. 2020. “Impacts of Stormwater on Coastal Ecosystems: The Need to Match the Scales of Management Objectives and Solutions.” Philosophical Transactions of the Royal Society B: Biological Sciences 375 (1814): 20190460. https://doi.org/10.1098/rstb.2019.0460.

Li, Chenguang, Yanlei Zhang, Shiqi Yin, et al. 2023. “First Insights into 6PPD-Quinone Formation from 6PPD Photodegradation in Water Environment.” Journal of Hazardous Materials 459 (October): 132127. https://doi.org/10.1016/j.jhazmat.2023.132127.

Liang, Bowen, Jiali Ge, Qing Deng, et al. 2024. “Occurrence of Multiple Classes of Emerging Synthetic Antioxidants, Including p -Phenylenediamines, Diphenylamines, Naphthylamines, Macromolecular Hindered Phenols, and Organophosphites, in Human Milk: Implications for Infant Exposure.” Environmental Science & Technology Letters 11 (3): 259–65. https://doi.org/10.1021/acs.estlett.4c00010.

Liang, Bowen, Jiehua Li, Bibai Du, Zibin Pan, Liang-Ying Liu, and Lixi Zeng. 2022. “E-Waste Recycling Emits Large Quantities of Emerging Aromatic Amines and Organophosphites: A Poorly Recognized Source for Another Two Classes of Synthetic Antioxidants.” Environmental Science & Technology Letters , June 30, acs.estlett.2c00366. https://doi.org/10.1021/acs.estlett.2c00366.

Liu, Runzeng, Yiling Li, Yongfeng Lin, Ting Ruan, and Guibin Jiang. 2019. “Emerging Aromatic Secondary Amine Contaminants and Related Derivatives in Various Dust Matrices in China.” Ecotoxicology and Environmental Safety 170 (April): 657–63. https://doi.org/10.1016/j.ecoenv.2018.12.036.

Lo, Bonnie P., Vicki L. Marlatt, Xiangjun Liao, et al. 2023. “Acute Toxicity of 6PPD‐Quinone to Early Life Stage Juvenile Chinook ( Oncorhynchus tshawytscha ) and Coho ( Oncorhynchus kisutch ) Salmon.” Environmental Toxicology and Chemistry 42 (4): 815–22. https://doi.org/10.1002/etc.5568.

Lokesh, Srinidhi, Siththarththan Arunthavabalan, Elie Hajj, Edgard Hitti, and Yu Yang. 2023. “Investigation of 6PPD-Quinone in Rubberized Asphalt Concrete Mixtures.” ACS Environmental Au , ahead of print, July 26. https://doi.org/10.1021/acsenvironau.3c00023.

Müller, Kathrin, Daniel Hübner, Sven Huppertsberg, Thomas P. Knepper, and Daniel Zahn. 2022. “Probing the Chemical Complexity of Tires: Identification of Potential Tire-Borne Water Contaminants with High-Resolution Mass Spectrometry.” Science of The Total Environment 802: 149799. https://doi.org/10.1016/j.scitotenv.2021.149799.

Mahoney, Hannah, Francisco C. da Silva Junior, Catherine Roberts, et al. 2022. “Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction In Vitro.” Environmental Science & Technology Letters 9 (9): 765–71. https://doi.org/10.1021/acs.estlett.2c00431.

Maji, Usha Jyoti, Kyuhyeong Kim, In-Cheol Yeo, Kyu-Young Shim, and Chang-Bum Jeong. 2023. “Toxicological Effects of Tire Rubber–Derived 6PPD-Quinone, a Species-Specific Toxicant, and Dithiobisbenzanilide (DTBBA) in the Marine Rotifer Brachionus koreanus .” Marine Pollution Bulletin 192 (July): 115002. https://doi.org/10.1016/j.marpolbul.2023.115002.

Mantua, Nathan, Ingrid Tohver, and Alan Hamlet. 2010. “Climate Change Impacts on Streamflow Extremes and Summertime Stream Temperature and Their Possible Consequences for Freshwater Salmon Habitat in Washington State.” Climatic Change 102 (1–2): 187–223. https://doi.org/10.1007/s10584-010-9845-2.

Mao, Weili, Hangbiao Jin, Ruyue Guo, Ping Chen, Songyang Zhong, and Xilin Wu. 2024. “Occurrence of p -Phenylenediamine Antioxidants in Human Urine.” Science of the Total Environment 914 (March): 170045. https://doi.org/10.1016/j.scitotenv.2024.170045.

Marques dos Santos, Mauricius, and Shane Allen Snyder. 2023. “Occurrence of Polymer Additives 1,3-Diphenylguanidine (DPG), N -(1,3-Dimethylbutyl)- N′ -Phenyl-1,4-Benzenediamine (6PPD), and Chlorinated Byproducts in Drinking Water: Contribution from Plumbing Polymer Materials.” Environmental Science & Technology Letters , ahead of print, September 6. https://doi.org/10.1021/acs.estlett.3c00446.

Masset, Thibault, Benoit J. D. Ferrari, William Dudefoi, et al. 2022. “Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion.” Environmental Science & Technology 56 (22): 15607–16. https://doi.org/10.1021/acs.est.2c04291.

Maurer, Loïc, Eric Carmona, Oliver Machate, Tobias Schulze, Martin Krauss, and Werner Brack. 2023. “Contamination Pattern and Risk Assessment of Polar Compounds in Snow Melt: An Integrative Proxy of Road Runoffs.” Environmental Science & Technology 57 (10): 4143–52. https://doi.org/10.1021/acs.est.2c05784.

Mayer, Paul, Kelly Moran, Ezra Miller, et al. 2024. “Where the Rubber Meets the Road: Emerging Environmental Impacts of Tire Wear Particles and Their Chemical Cocktails.” Science of The Total Environment 927 (June): 171153. https://doi.org/10.1016/j.scitotenv.2024.171153.

McHugh, Chris. 2023. Wastewater Sampling . LSASDPROC-306-R6 042223. Region 4 U.S. Environmental Protection Agency Laboratory Services & Applied Science Division. https://www.epa.gov/sites/default/files/2017-07/documents/wastewater_sampling306_af.r4.pdf.

McIntyre, J. K., J. W. Davis, J. P. Incardona, John D. Stark, B. F. Anulacion, and N. L. Scholz. 2014. “Zebrafish and Clean Water Technology: Assessing Soil Bioretention as a Protective Treatment for Toxic Urban Runoff.” Science of the Total Environment 500: 173–80. https://doi.org/10.1016/j.scitotenv.2014.08.066.

McIntyre, Jenifer K., Jasmine Prat, James Cameron, et al. 2021. “Treading Water: Tire Wear Particle Leachate Recreates an Urban Runoff Mortality Syndrome in Coho but Not Chum Salmon.” Environmental Science & Technology 55 (17): 11767–74. https://doi.org/10.1021/acs.est.1c03569.

McIntyre, Jenifer, Jessica Lundin, James Cameron, et al. 2018. “Interspecies Variation in the Susceptibility of Adult Pacific Salmon to Toxic Urban Stormwater Runoff.” Environmental Pollution 238: 196–203. https://doi.org/https://doi.org/10.1016/j.envpol.2018.03.012.

McIntyre, Jenifer, Julann Spromberg, James Cameron, John P. Incardona, Jay W. Davis, and Nathaniel L. Scholz. 2023. “Bioretention Filtration Prevents Acute Mortality and Reduces Chronic Toxicity for Early Life Stage Coho Salmon ( Oncorhynchus kisutch ) Episodically Exposed to Urban Stormwater Runoff.” Science of the Total Environment 902 (December): 165759. https://doi.org/10.1016/j.scitotenv.2023.165759.

Milani, M., F. P. Pucillo, M. Ballerini, M. Camatini, M. Gualtieri, and S. Martino. 2004. “First Evidence of Tyre Debris Characterization at the Nanoscale by Focused Ion Beam.” Materials Characterization 52 (4–5): 283–88. https://doi.org/10.1016/j.matchar.2004.06.001.

Mitchell, Chelsea J., and Anand D. Jayakaran. 2024. “Mitigating Tire Wear Particles and Tire Additive Chemicals in Stormwater with Permeable Pavements.” Science of the Total Environment 908 (January): 168236. https://doi.org/10.1016/j.scitotenv.2023.168236.

Monaghan, Joseph, Angelina Jaeger, Alon R. Agua, et al. 2021. “A Direct Mass Spectrometry Method for the Rapid Analysis of Ubiquitous Tire-Derived Toxin N -(1,3-Dimethylbutyl)- N′ -Phenyl- p -Phenylenediamine Quinone (6-PPDQ).” Environmental Science & Technology Letters 8 (12): 1051–56. https://doi.org/10.1021/acs.estlett.1c00794.

Monsanto Company. 1965. Preservation of Diene Rubbers (Great Britain Patent No. 1035262A). Patent 1035262A, issued 1965.

Monsanto Company. 1979. Dynamic Toxicity of Santoflex 13 to Fatheads Minnows ( Pimephales promelas ). Curated Toxicity Data Were Retrieved from the ECOTOXicology Knowledgebase, U.S. Environmental Protection Agency. Http:/Www.Epa.Gov/Ecotox/ (November 10, 2023). Nos. 21850-A/AB-780121B. St. Louis, Missouri.

Montgomery, David, Xiaowen Ji, Jenna Cantin, et al. 2023. “Not Yet Peer Reviewed: Toxicokinetic Characterization of the Inter-Species Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semi-Quantification.” Preprint, bioRxiv, August 20. https://doi.org/10.1101/2023.08.18.553920.

Moran, Kelly, Alicia Gilbreath, Miguel Mendez, Diana Lin, and Rebecca Sutton. 2023. Tire Wear: Emissions Estimates and Market Insights to Inform Monitoring Design . SFEI Technical Report SFEI Contribution #1049. San Francisco Estuary Institute.

More, Sharlee L., Julie V. Miller, Stephanie A. Thornton, Kathy Chan, Timothy R. Barber, and Kenneth M. Unice. 2023. “Refinement of a Microfurnace Pyrolysis-GC–MS Method for Quantification of Tire and Road Wear Particles (TRWP) in Sediment and Solid Matrices.” Science of the Total Environment 874 (May): 162305. https://doi.org/10.1016/j.scitotenv.2023.162305.

NOAA Fisheries. 2022. “In the Spotlight: Southern Resident Killer Whale.” January 4. https://www.fisheries.noaa.gov/species/killer-whale/spotlight.

NOAA Fisheries. 2023. “Ecosystem Interactions and Pacific Salmon | NOAA Fisheries.” NOAA, August 31. https://www.fisheries.noaa.gov/west-coast/sustainable-fisheries/ecosystem-interactions-and-pacific-salmon.

NOAA Fisheries. 2023. “Laws & Policies: Magnuson-Stevens Act | NOAA Fisheries.” NOAA, December 6. https://www.fisheries.noaa.gov/topic/laws-policies.

NOAA Fisheries. 2023. “Magnuson-Stevens Fishery Conservation and Management Act | NOAA Fisheries.” NOAA, June 15. https://www.fisheries.noaa.gov/resource/document/magnuson-stevens-fishery-conservation-and-management-act.

NOAA Fisheries. 2023. “Sovereign Relations on the West Coast | NOAA Fisheries.” NOAA, October 24. https://www.fisheries.noaa.gov/west-coast/partners/sovereign-relations-west-coast.

NOAA Fisheries. 2023. “Steelhead Trout | NOAA Fisheries.” NOAA, February 9. https://www.fisheries.noaa.gov/species/steelhead-trout.

NOAA Fisheries. 2024. “Coho Salmon (Protected) | NOAA Fisheries.” NOAA, January 17. https://www.fisheries.noaa.gov/species/coho-salmon-protected.

NOAA Fisheries. 2024. “Endangered Species Action Consultations | NOAA Fisheries.” NOAA, January 22. https://www.fisheries.noaa.gov/topic/consultations.

Naiman, Bilby, Schindler, and Helfield. 2002. “Pacific Salmon, Nutrients, and the Dynamics of Freshwater and Riparian Ecosystems.” Ecosystems 5: 399–417.

Nair, Pranav, Jianxian Sun, Linna Xie, et al. 2023. “In Process: Synthesis and Toxicity Evaluation of Tire Rubber–Derived Quinones.” Preprint. Chemistry, June 20. https://doi.org/10.26434/chemrxiv-2023-pmxvc.

National Toxicology Program, Public Health Service U.S. Department of Health and Human Services. 2019. NTP Research Report on the Chemical and Physical Characterization of Recycled Tire Crumb Rubber . Research Report No. 11. https://ntp.niehs.nih.gov/go/rr11abs.

Navickis-Brasch, Aimee, Mark Maurer, Taylor Hoffman-Ballard, Susan Bator, and Jerry Diamond. 2022. Stormwater Treatment of Tire Contaminants Best Management Practices Effectiveness . https://fortress.wa.gov/ecy/ezshare/wq/Permits/Flare/2019SWMMWW/Content/Resources/DocsForDownload/2022_SWTreatmentOfTireContaminants-BMPEffectiveness.pdf.

Nedrich, Sara. 2022. Preliminary Investigation of the Occurrence of 6PPD-Quinone in Michigan’s Surface Water . https://doi.org/10.13140/RG.2.2.34478.59204.

Neilson, Leighanne. 2021. “SGS AXYS Measures the Major Antiozonant Degradation Product 6-PPD Quinone and 6-PPD.” SGS AXYS, December 14. https://www.sgsaxys.com/2021/12/14/new-sgs-axys-is-pleased-to-measure-the-major-antiozonant-degradation-product-6-ppd-quinone-and-its-parent-compound-6-ppd-at-sub-ng-l-reporting-limits/.

OECD. 2004. SIDS Initial Assessment Report for N-(1,3-Dimethylbutyl)-N´-Phenyl-1,4-Phenylenediamine (6PPD), Organisation for Economic Co-Operation and Development (OECD) . https://hpvchemicals.oecd.org/UI/handler.axd?id=5e1a446c-5969-479c-9270-7ced8726952e.

OECD. 2021. “Mitigation Technologies and Best Practices.” In Policies to Reduce Microplastics Pollution in Water . OECD. https://doi.org/10.1787/156bdfa5-en.

OSPAR Commission. 2006. Hazardous Substances Series 4-(Dimethylbutylamino)Diphenylamine (6PPD) 2005 (2006 Update) . Publication Number: 271/2006. https://www.ospar.org/documents?v=7029.

Ofner, Robert. 1967. Information Sources on Rubber for Engineers and Designers . U.S. Army Weapons Command. Rock Island Arsenal: Research and Engineering Division. https://apps.dtic.mil/sti/tr/pdf/AD0660315.pdf.

Olubusoye, Boluwatife S., James V. Cizdziel, Matthew Bee, et al. 2023. “Toxic Tire Wear Compounds (6PPD-Q and 4-ADPA) Detected in Airborne Particulate Matter Along a Highway in Mississippi, USA.” Bulletin of Environmental Contamination and Toxicology 111 (6): 68. https://doi.org/10.1007/s00128-023-03820-7.

Panko, Julie M., Jennifer Chu, Marisa L. Kreider, and Ken M. Unice. 2013. “Measurement of Airborne Concentrations of Tire and Road Wear Particles in Urban and Rural Areas of France, Japan, and the United States.” Atmospheric Environment 72 (June): 192–99. https://doi.org/10.1016/j.atmosenv.2013.01.040.

Panko, Julie M., Kristen M. Hitchcock, Gary W. Fuller, and David Green. 2019. “Evaluation of Tire Wear Contribution to PM _2.5 in Urban Environments.” Atmosphere 10 (2): 99. https://doi.org/10.3390/atmos10020099.

Park, Inyong, Hongsuk Kim, and Seokhwan Lee. 2018. “Characteristics of Tire Wear Particles Generated in a Laboratory Simulation of Tire/Road Contact Conditions.” Journal of Aerosol Science 124 (October): 30–40. https://doi.org/10.1016/j.jaerosci.2018.07.005.

Peter, Katherine T., Fan Hou, Zhenyu Tian, et al. 2020. “More than a First Flush: Urban Creek Storm Hydrographs Demonstrate Broad Contaminant Pollutographs.” Environmental Science & Technology 54 (10): 6152–65. https://doi.org/10.1021/acs.est.0c00872.

Philibert, Danielle, Ryan S. Stanton, Christine Tang, et al. 2024. “The Lethal and Sublethal Impacts of Two Tire Rubber–Derived Chemicals on Brook Trout ( Salvelinus fontinalis ) Fry and Fingerlings.” Chemosphere , ahead of print, May 10. https://doi.org/10.1016/j.chemosphere.2024.142319.

Poldushova, G. A., K. L. Kandyrin, and S. V. Reznichenko. 2016. “The Effect of the Structure of p -Phenylenediamine Antiagers on the Physicomechanical and Hysteresis Properties of Filled Rubber Compounds.” International Polymer Science and Technology 43 (2): 19–22. https://doi.org/10.1177/0307174X1604300205.

Prosser, R. S., A. J. Bartlett, D. Milani, et al. 2017. “Variation in the Toxicity of Sediment-Associated Substituted Phenylamine Antioxidants to an Epibenthic ( Hyalella azteca ) and Endobenthic ( Tubifex tubifex ) Invertebrate.” Chemosphere 181 (August): 250–58. https://doi.org/10.1016/j.chemosphere.2017.04.066.

Prosser, R. S., J. Salole, and S. Hang. 2023. “Toxicity of 6PPD-Quinone to Four Freshwater Invertebrate Species.” Environmental Pollution , September 4, 122512. https://doi.org/10.1016/j.envpol.2023.122512.

Prosser, R. S., P. L. Gillis, E. A. M. Holman, et al. 2017. “Effect of Substituted Phenylamine Antioxidants on Three Life Stages of the Freshwater Mussel Lampsilis siliquoidea .” Environmental Pollution 229: 281–89. https://doi.org/10.1016/j.envpol.2017.05.086.

Prosser, Ryan S., Joanne L. Parrott, Melissa Galicia, et al. 2017. “Toxicity of Sediment-Associated Substituted Phenylamine Antioxidants on the Early Life Stages of Pimephales promelas and a Characterization of Effects on Freshwater Organisms.” Environmental Toxicology and Chemistry 36 (10): 2730–38. https://doi.org/10.1002/etc.3828.

PubChem. 2021. “N-(1,3-Dimethylbutyl)-N’-Phenyl-p-Phenylenediamine.” January. https://pubchem.ncbi.nlm.nih.gov/compound/13101.

Puget Soundkeeper. 2022. “Puget Sound Municipalities Fail to Address 6PPD-Quinone, Putting Salmon at Risk.” Puget Soundkeeper Alliance, June 16. https://pugetsoundkeeper.org/2022/06/16/6ppd-mukilteo-burien-seatac-normandy-park-seattle/.

Pulford, C. 1983. Antioxidant Effects during Blade Abrasion of Natural Rubber . 28: 709–13.

Qian, Yiguang, Ziyu Chen, Jiahui Wang, et al. 2023. “H/D Exchange Coupled with 2H-Labeled Stable Isotope–Assisted Metabolomics Discover Transformation Products of Contaminants of Emerging Concern.” Analytical Chemistry 95 (33): 12541–49. https://doi.org/10.1021/acs.analchem.3c02833.

Rødland, Elisabeth S., Mats Gustafsson, David Jaramillo-Vogel, et al. 2023. “Analytical Challenges and Possibilities for the Quantification of Tire-Road Wear Particles.” TrAC Trends in Analytical Chemistry 165: 117121. https://doi.org/10.1016/j.trac.2023.117121.

Rauert, Cassandra, Jasmin K. Schuster, Anita Eng, and Tom Harner. 2018. “Global Atmospheric Concentrations of Brominated and Chlorinated Flame Retardants and Organophosphate Esters.” Environmental Science & Technology 52 (5): 2777–89. https://doi.org/10.1021/acs.est.7b06239.

Rauert, Cassandra, Nathan Charlton, Elvis D. Okoffo, et al. 2022. “Concentrations of Tire Additive Chemicals and Tire Road Wear Particles in an Australian Urban Tributary.” Environmental Science & Technology , ahead of print, January 31. World. https://doi.org/10.1021/acs.est.1c07451.

Rauert, Cassandra, Suzanne Vardy, Benjamin Daniell, Nathan Charlton, and Kevin V. Thomas. 2022. “Tyre Additive Chemicals, Tyre Road Wear Particles and High Production Polymers in Surface Water at 5 Urban Centres in Queensland, Australia.” Science of The Total Environment 852: 158468. https://doi.org/10.1016/j.scitotenv.2022.158468.

Razumovskii, S. D., and L. S. Batashova. 1970. “Mechanism of Protection against Ozone by N-Phenyl-N′-Isopropyl- p- Phenylenediamine.” Rubber Chemistry and Technology 43 (6): 1340–48. https://doi.org/10.5254/1.3547334.

Redman, Zachary C., Jessica L. Begley, Isabel Hillestad, et al. 2023. “Reactive Oxygen Species and Chromophoric Dissolved Organic Matter Drive the Aquatic Photochemical Pathways and Photoproducts of 6PPD-Quinone under Simulated High-Latitude Conditions.” Environmental Science & Technology 57 (49): 20813–21. https://doi.org/10.1021/acs.est.3c05742.

Roberts, Catherine, Junyi Lin, Evan Kohlman, et al. 2024. “Acute and Sub-Chronic Toxicity of 6PPD-Quinone to Early-Life Stage Lake Trout ( Salvelinus namaycush ).” Preprint, bioRxiv, April 3. https://doi.org/10.1101/2024.03.26.586843.

Rodgers, Timothy F. M., Yanru Wang, Cassandra Humes, et al. 2023. “Bioretention Cells Provide a 10-Fold Reduction in 6PPD-Quinone Mass Loadings to Receiving Waters: Evidence from a Field Experiment and Modeling.” Environmental Science & Technology Letters , ahead of print, June 16. https://doi.org/10.1021/acs.estlett.3c00203.

Rossomme, Elliot, William M. Hart-Cooper, William J. Orts, Colleen M. McMahan, and Martin Head-Gordon. 2023. “Computational Studies of Rubber Ozonation Explain the Effectiveness of 6PPD as an Antidegradant and the Mechanism of Its Quinone Formation.” Environmental Science & Technology , March 24, acs.est.2c08717. https://doi.org/10.1021/acs.est.2c08717.

Rowangould, G. M. 2013. “A Census of the US Near-Roadway Population: Public Health and Environmental Justice Considerations.” Transportation Research, Part D: Transport and Environment 2013 (25): 59–67. https://doi.org/10.1016/j.trd.2013.08.003.

Saifur, Sumaiya, and Courtney M Gardner. 2023. “Evaluation of Stormwater Microbiomes for the Potential Biodegradation of Tire Wear Particle Contaminants.” Journal of Applied Microbiology 134 (5): lxad086. https://doi.org/10.1093/jambio/lxad086.

Saini, Amandeep, Tom Harner, Sita Chinnadhurai, et al. 2020. “GAPS-Megacities: A New Global Platform for Investigating Persistent Organic Pollutants and Chemicals of Emerging Concern in Urban Air.” Environmental Pollution 267 (December): 115416. https://doi.org/10.1016/j.envpol.2020.115416.

Santoso, M., U. Giese, and R. H. Schuster. 2007. Investigations on Initial Stage of Aging of Tire Rubbers by Chemiluminescence Spectroscopy . 80: 762–76. https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/5714930.

Schönenberger, Urs, Michael Patrick, Simon Wullschleger, and Christian Stamm. 2020. “A Water-Level Proportional Water Sampler for Remote Areas.” Zenodo . https://zenodo.org/records/4280534.

Schneider, Klaus, Manfred De Hoogd, Maria Pelle Madsen, Pascal Haxaire, Anne Bierwisch, and Eva Kaiser. 2020. “ERASSTRI — European Risk Assessment Study on Synthetic Turf Rubber Infill — Part 1: Analysis of Infill Samples.” Science of The Total Environment 718: 137174. https://doi.org/10.1016/j.scitotenv.2020.137174.

Schneider, Klaus, Manfred De Hoogd, Pascal Haxaire, Arne Philipps, Anne Bierwisch, and Eva Kaiser. 2020. “ERASSTRI — European Risk Assessment Study on Synthetic Turf Rubber Infill — Part 2: Migration and Monitoring Studies.” Science of The Total Environment 718: 137173. https://doi.org/10.1016/j.scitotenv.2020.137173.

Scholz, Nathaniel L., Mark S. Myers, Sarah G. McCarthy, et al. 2011. “Recurrent Die-Offs of Adult Coho Salmon Returning to Spawn in Puget Sound Lowland Urban Streams.” PLOS ONE 6 (12): e28013. https://doi.org/10.1371/journal.pone.0028013.

Scott, Gerald. 1985. “A Review of Recent Developments in the Mechanisms of Antifatigue Agents.” Rubber Chemistry and Technology 58 (2): 269–83. https://doi.org/10.5254/1.3536065.

Seebacher, Lizbeth Ann, Brianna Pierce, and Rob Turner. 2023. “Floating Treatment Wetland and Biomedia Module for Stormwater Treatment and 6ppd Quinone Removal.” Preprint. https://doi.org/10.2139/ssrn.4471002.

Seiwert, Bettina, Maolida Nihemaiti, Mareva Troussier, Steffen Weyrauch, and Thorsten Reemtsma. 2022. “Abiotic Oxidative Transformation of 6-PPD and 6-PPD Quinone from Tires and Occurrence of Their Products in Snow from Urban Roads and in Municipal Wastewater.” Water Research 212: 118122. https://doi.org/10.1016/j.watres.2022.118122.

Seiwert, Bettina, Philipp Klöckner, Stephan Wagner, and Thorsten Reemtsma. 2020. “Source-Related Smart Suspect Screening in the Aqueous Environment: Search for Tire-Derived Persistent and Mobile Trace Organic Contaminants in Surface Waters.” Analytical and Bioanalytical Chemistry 412 (20): 4909–19. https://doi.org/10.1007/s00216-020-02653-1.

Shankar, Prarthana, Ellie M. Dalsky, Joanne E Salzer, et al. 2024. “Evaluation of Lethal and Sublethal Effects of 6PPD-Q on Coastal Cutthroat Trout (Oncorhynchus Clarkii Clarkii).” Preprint, U.S. Geological Survey. Csv,xml. https://doi.org/10.5066/P16SMKIJ.

Shelton, Larry R. 1994. Field Guide for Collecting and Processing Stream-Water Samples for the National Water-Quality Assessment Program . USGS Numbered Series Open-File Report Nos. 94–455. U.S. Geological Survey.

Sherman, Anya, Luzian Elijah Hämmerle, Evyatar Ben Mordechay, Benny Chefetz, Thorsten Hüffer, and Thilo Hofmann. 2024. “Uptake of Tire-Derived Compounds in Leafy Vegetables and Implications for Human Dietary Exposure.” Frontiers in Environmental Science 12 (May). https://doi.org/10.3389/fenvs.2024.1384506.

Sherman, Anya, Thibault Masset, Lukas Wimmer, et al. 2024. “The Invisible Footprint of Climbing Shoes: High Exposure to Rubber Additives in Indoor Facilities.” Preprint. https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65b74ca0e9ebbb4db9311694/original/the-invisible-footprint-of-climbing-shoes-high-exposure-to-rubber-additives-in-indoor-facilities.pdf.

Shetye, Sugandha S., and Satish N. Ambare. 2018. “Pyrolysis Gas Chromatography Mass Spectrometry: A Efficient Technique for Identification and Quantification of Rubber Antioxident P-Phenylene Diamine (6PPD).” International Journal of Research and Analytical Reviews 5 (2): 949–54. http://ijrar.com/upload_issue/ijrar_issue_920.pdf.

Sieber, Ramona, Delphine Kawecki, and Bernd Nowack. 2020. “Dynamic Probabilistic Material Flow Analysis of Rubber Release from Tires into the Environment.” Environmental Pollution 258: 113573. https://doi.org/10.1016/j.envpol.2019.113573.

Skoczyńska, Ewa, Pim E. G. Leonards, Maria Llompart, and Jacob de Boer. 2021. “Analysis of Recycled Rubber: Development of an Analytical Method and Determination of Polycyclic Aromatic Hydrocarbons and Heterocyclic Aromatic Compounds in Rubber Matrices.” Chemosphere 276: 130076. https://doi.org/10.1016/j.chemosphere.2021.130076.

Smith, Albert K., and Dann Sklarew. 2013. “A Mid Atlantic Brook Trout ( Salvelinus fontinalis ) Stream Sustainability Statistic for Rating Non-Tidal Streams.” Sustainability of Water Quality and Ecology 1–2 (December): 68–81. https://doi.org/10.1016/j.swaqe.2013.08.001.

Snover, A.K., C.L. Raymond, H.A. Roop, and H. Morgan. 2019. No Time to Waste. The Intergovernmental Panel on Climate Change’s Special Report on Global Warming of 1.5°C and Implications for Washington State . Briefing Paper Prepared by the Climate Impacts Group, University of Washington, Seattle. https://cig.uw.edu/wp-content/uploads/sites/2/2019/02/NoTimeToWaste_CIG_Feb2019.pdf.

Spromberg, Julann A, and Nathaniel L Scholz. 2011. “Estimating the Future Decline of Wild Coho Salmon Populations Resulting from Early Spawner Die-Offs in Urbanizing Watersheds of the Pacific Northwest, USA.” Integrated Environmental Assessment and Management 7 (4): 648–56. https://doi.org/10.1002/ieam.219.

Spromberg, Julann A., David H. Baldwin, Steven E. Damm, et al. 2016. “Coho Salmon Spawner Mortality in Western US Urban Watersheds: Bioinfiltration Prevents Lethal Storm Water Impacts.” Journal of Applied Ecology 53 (2): 398–407. https://doi.org/https://doi.org/10.1111/1365-2664.12534.

Sustainable Chemistry Catalyst. 2023. Collaborative Innovation Forum: Functional Substitutes to 6PPD in Tires. Meeting Report . https://static1.squarespace.com/static/633b3dd6649ed62926ed7271/t/63ee6cd15eb30a0fd4f0630d/1676569810601/6PPD-in-Tires-Innovation-Forum-Meeting-Report.pdf.

Tamis, Jacqueline E., Albert A. Koelmans, Rianne Dröge, et al. 2021. “Environmental Risks of Car Tire Microplastic Particles and Other Road Runoff Pollutants.” Microplastics and Nanoplastics 1 (1): 10. https://doi.org/10.1186/s43591-021-00008-w.

Testimony of David Troutt (2021). https://democrats-naturalresources.house.gov/imo/media/doc/2021_07_15_Written%20Testimony_David%20Troutt.pdf.

Tian, Nancy, Jianping Xue, and Timothy M. Barzyk. 2013. “Evaluating Socioeconomic and Racial Differences in Traffic-Related Metrics in the United States Using a GIS Approach.” Journal of Exposure Science & Environmental Epidemiology 23 (2): 215–22. https://doi.org/10.1038/jes.2012.83.

Tian, Zhenyu, Haoqi Zhao, Katherine T. Peter, et al. 2021. “A Ubiquitous Tire Rubber–Derived Chemical Induces Acute Mortality in Coho Salmon.” Report. Science 371 (6525): 185–89. https://doi.org/10.1126/science.abd6951.

Tian, Zhenyu, Melissa Gonzalez, Craig A. Rideout, et al. 2022. “6PPD-Quinone: Revised Toxicity Assessment and Quantification with a Commercial Standard.” Environmental Science & Technology Letters , January 11, acs.estlett.1c00910. https://doi.org/10.1021/acs.estlett.1c00910.

Tiwari, Arvind, Prashant Kumar, Richard Baldauf, et al. 2019. “Considerations for Evaluating Green Infrastructure Impacts in Microscale and Macroscale Air Pollution Dispersion Models.” Science of the Total Environment 672: 410–26. https://doi.org/10.1016/j.scitotenv.2019.03.350.

Tonegawa, Yoshio, and Sousuke Sasaki. 2021. “Development of Tire-Wear Particle Emission Measurements for Passenger Vehicles.” Emission Control Science and Technology 7 (1): 56–62. https://doi.org/10.1007/s40825-020-00181-z.

ToxServices, LLC. 2021. N-(1,3-Dimethylbutyl)-N’-Phenyl-p-Phenylenediamine (6PPD) (CAS #793-24-8) Greenscreen® for Safer Chemicals (Greenscreen®) Assessment . GS-1204. ToxServices Toxicology Risk Assessment Consulting. https://www.ezview.wa.gov/Portals/_1962/Documents/6ppd/GreenScreenExecutiveSummaryFor6PPD.pdf.

USEPA, Region 10. 2017. “NPDES Stormwater Permit for Joint Base Lewis-McChord MS4 in Washington.” Reports and Assessments. September 29. https://www.epa.gov/npdes-permits/npdes-stormwater-permit-joint-base-lewis-mcchord-ms4-washington.

USEPA. 1975. Environmental Aspects of Chemical Use in Rubber Processing Operations . EPA-560/1-75-002; Office of Toxic Substances. https://nepis.epa.gov/Exe/ZyPDF.cgi/2000IUPB.PDF?Dockey=2000IUPB.PDF.

USEPA. 2002. Guidance on Choosing a Sampling Design for Environmental Data Collection for Use in Developing a Quality Assurance Project Plan . EPA QA/G-5S. Office of Environmental Information. https://www.epa.gov/sites/default/files/2015-06/documents/g5s-final.pdf.

USEPA. 2002. Guidelines for Reviewing TMDLs under Existing Regulations Issued in 1992 . https://www.epa.gov/sites/default/files/2015-10/documents/2002_06_04_tmdl_guidance_final52002.pdf.

USEPA. 2004. NPDES Compliance Inspection Manual . EPA 305-X-04-001. Office of Enforcement and Compliance Assurance. https://www.epa.gov/sites/default/files/2013-09/documents/npdesinspect_0.pdf.

USEPA. 2004. Understanding the Safe Drinking Water Act . June.

USEPA. 2011. “Exposure Factors Handbook 2011 Edition (Final Report).” U.S. Environmental Protection Agency, Washington, DC.

USEPA. 2012. 7. Estimating Persistence, Bioaccumulation, and Toxicity Using the PBT Profiler . EPA-748-B12-001. Sustainable Futures / P2 Framework Manual. https://www.epa.gov/sites/default/files/2015-05/documents/07.pdf.

USEPA. 2015. “Resource Conservation and Recovery Act (RCRA) Overview.” Other Policies and Guidance. August 18. https://www.epa.gov/rcra/resource-conservation-and-recovery-act-rcra-overview.

USEPA. 2015. “Stormwater Discharges from Municipal Sources—Developing an MS4 Program.” Overviews and Factsheets. November 2. https://www.epa.gov/npdes/stormwater-discharges-municipal-sources.

USEPA. 2015. “Stormwater Discharges from Transportation Sources.” Overviews and Factsheets. November 3. https://www.epa.gov/npdes/stormwater-discharges-transportation-sources.

USEPA. 2017. “Living Close to Roadways: Health Concerns and Mitigation Strategies.” Overviews and Factsheets. January 10. https://www.epa.gov/sciencematters/living-close-roadways-health-concerns-and-mitigation-strategies.

USEPA. 2017. NPDES Compliance Inspection Manual Chapter 5 — Sampling . Interim Revised Version. https://www.epa.gov/sites/default/files/2017-03/documents/npdesinspect-chapter-05.pdf.

USEPA. 2021. Industrial Stormwater Monitoring and Sampling Guide . EPA 832-B-09-003. https://www.epa.gov/sites/default/files/2015-11/documents/msgp_monitoring_guide.pdf.

USEPA. 2022. “Superfund: CERCLA Overview.” U.S. Environmental Protection Agency, February. https://www.epa.gov/superfund/superfund-cercla-overview.

USEPA. 2023. “6PPD-Quinone.” Overviews and Factsheets. August 9. https://www.epa.gov/chemical-research/6ppd-quinone.

USEPA. 2023. “Air Data: Air Quality Data Collected at Outdoor Monitors Across the US.” Collections and Lists. November 9. https://www.epa.gov/outdoor-air-quality-data.

USEPA. 2023. “Chemicals under the Toxic Substances Control Act (TSCA).” Collections and Lists. August 16. https://www.epa.gov/chemicals-under-tsca.

USEPA. 2023. “EPA Grants Tribal Petition to Protect Salmon from Lethal Chemical.” News Release. November 2. https://www.epa.gov/newsreleases/epa-grants-tribal-petition-protect-salmon-lethal-chemical.

USEPA. 2023. Draft Method 1634: Determination of 6PPD-Quinone in Aqueous Matrices Using Liquid Chromatography with Tandem Mass Spectrometry (LC/MS/MS) . EPA 821-D-24-001. Office of Water (4303T), Office of Science and Technology. https://www.epa.gov/system/files/documents/2024-01/draft-method-1634-for-web-posting-1-23-24_508.pdf.

USEPA. 2023. Estimation Programs Interface Suite ^TM for Microsoft® Windows, v 4.11 (EPISuite) . V. v 4.11. Released. https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface.

USEPA. 2024. “Heat Islands and Equity.” July 16. https://www.epa.gov/heatislands/heat-islands-and-equity.

USEPA. n.d. “CompTox Chemicals Dashboard: 6PPD - Chemical Details.” https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025114.

USEPA. n.d. “CompTox Chemicals Dashboard: 6PPD-Quinone - Chemical Details.” https://comptox.epa.gov/dashboard/chemical/details/DTXSID301034849.

USFWS, NOAA, and Washington State University. 2019. “Predicted Mean Annual Coho Runoff Mortality Syndrome Rates Across the Puget Sound.” https://www.arcgis.com/apps/webappviewer/index.html?id=53ea11d4125146628026b80241716962.

USFWS. 1998. “ESA Section 7 Consultation.” Fish, March 1. https://www.fws.gov/service/esa-section-7-consultation.

USFWS. 2000. “Rainbow Trout ( Oncorhynchus mykiss ) | U.S. Fish & Wildlife Service.” July 10. https://www.fws.gov/species/rainbow-trout-oncorhynchus-mykiss.

USGS. 2023. “Brook Trout ( Salvelinus fontinalis ) —  Species Profile. United States Geological Survey (USGS).” USGS Nonindigenous Aquatic Species Database. https://nas.er.usgs.gov/queries/factsheet.aspx?SpeciesID=939.

USGS. 2023. “Coho Salmon ( Oncorhynchus kisutch ) — Species Profile.” USGS Nonindigenous Aquatic Species Database. https://nas.er.usgs.gov/queries/factsheet.aspx?SpeciesID=908.

USTMA, U. S. Tire Manufacturers Association. 2022. “2021 US Scrap Tire Management Summary.” October 25. https://www.ustires.org/sites/default/files/21%20US%20Scrap%20Tire%20Management%20Report%20101722.pdf.

USTMA. 2024. USTMA Consortium Preliminary (Stage 1) Alternatives Analysis Report for CA DTSC . https://www.ustires.org/sites/default/files/2024-03/USTMA%20Consortium%206PPD%20AA%20Preliminary%20Report_3-25-24.pdf.

Unice, K. M., Jennifer Bare, Marisa Kreider, and Julie Panko. 2015. “Experimental Methodology for Assessing the Environmental Fate of Organic Chemicals in Polymer Matrices Using Column Leaching Studies and OECD 308 Water/Sediment Systems: Application to Tire and Road Wear Particles.” Science of the Total Environment 533 (July): 476–87. https://doi.org/10.1016/j.scitotenv.2015.06.053.

Unice, K. M., M. P. Weeber, M. M. Abramson, et al. 2019. “Characterizing Export of Land-Based Microplastics to the Estuary — Part I: Application of Integrated Geospatial Microplastic Transport Models to Assess Tire and Road Wear Particles in the Seine Watershed.” Science of the Total Environment 646: 1639–49. https://doi.org/10.1016/j.scitotenv.2018.07.368.

Unice, K.M., Marisa L. Kreider, and Julie M. Panko. 2013. “Comparison of Tire and Road Wear Particle Concentrations in Sediment for Watersheds in France, Japan, and the United States by Quantitative Pyrolysis GC/MS Analysis.” Environmental Science & Technology 47 (15): 8138–47. https://doi.org/10.1021/es400871j.

Varshney, Shubham, Adnan H. Gora, Prabhugouda Siriyappagouder, Viswanath Kiron, and Pål A. Olsvik. 2022. “Toxicological Effects of 6PPD and 6PPD Quinone in Zebrafish Larvae.” Journal of Hazardous Materials 424 (February): 127623. https://doi.org/10.1016/j.jhazmat.2021.127623.

Verschoor, A. J., and E. De Valk. 2018. Potential Measures against Microplastic Emissions to Water . RIVM. https://rivm.openrepository.com/rivm/handle/10029/622058, DOI:10.21945/RIVM-2017-0193.

WA Ecology. n.d. “6PPD - Washington State Department of Ecology.” Accessed July 25, 2024. https://ecology.wa.gov/waste-toxics/reducing-toxic-chemicals/addressing-priority-toxic-chemicals/6ppd.

Wagner, Stephan, Thorsten Hüffer, Philipp Klöckner, Maren Wehrhahn, Thilo Hofmann, and Thorsten Reemtsma. 2018. “Tire Wear Particles in the Aquatic Environment — A Review on Generation, Analysis, Occurrence, Fate and Effects.” Water Research 139 (August): 83–100. https://doi.org/10.1016/j.watres.2018.03.051.

Walsh, Christopher J., Allison H. Roy, Jack W. Feminella, Peter D. Cottingham, Peter M. Groffman, and Raymond P. Morgan. 2005. “The Urban Stream Syndrome: Current Knowledge and the Search for a Cure.” Journal of the North American Benthological Society 24 (3): 706–23. https://doi.org/10.1899/04-028.1.

Wang, Wei, Guodong Cao, Jing Zhang, et al. 2022. “Beyond Substituted p -Phenylenediamine Antioxidants: Prevalence of Their Quinone Derivatives in PM _2.5 .” Environmental Science & Technology , July 14, acs.est.2c02463. https://doi.org/10.1021/acs.est.2c02463.

Wang, Wei, Guodong Cao, Jing Zhang, et al. 2022. “ p -Phenylenediamine-Derived Quinones as New Contributors to the Oxidative Potential of Fine Particulate Matter.” Environmental Science & Technology Letters , August 10, acs.estlett.2c00484. https://doi.org/10.1021/acs.estlett.2c00484.

Wang, Xiaoliang, Steven Gronstal, Brenda Lopez, et al. 2023. “Evidence of Non-Tailpipe Emission Contributions to PM _2.5 and PM ₁₀ near Southern California Highways.” Environmental Pollution 317: 120691. https://doi.org/10.1016/j.envpol.2022.120691.

Wang, Yuxing, Xin Hua, and Dayong Wang. 2023. “Exposure to 6-PPD Quinone Enhances Lipid Accumulation through Activating Metabolic Sensors of SBP-1 and MDT-15 in Caenorhabditis elegans .” Environmental Pollution 333 (September): 121937. https://doi.org/10.1016/j.envpol.2023.121937.

Washington State Department of Ecology. 2018. “Technical Guidance Manual for Evaluating Emerging Stormwater Treatment Technologies.” Washington State Department of Ecology, September. https://apps.ecology.wa.gov/publications/documents/1810038.pdf.

Washington State Department of Ecology. 2021. “Technical Memo: Assessment of Potential Hazards of 6PPD and Alternatives.” November 29. https://www.ezview.wa.gov/Portals/_1962/Documents/6ppd/6PPD%20Alternatives%20Technical%20Memo.pdf.

Washington State Department of Ecology. 2022. 6PPD in Road Runoff Assessment and Mitigation Strategies . Nos. 22-03–020. Environmental Assessment and Water Quality Programs. https://apps.ecology.wa.gov/publications/documents/2203020.pdf.

Washington State Department of Ecology. 2023. “Municipal Stormwater Permit Reissuance—Washington State Department of Ecology.” https://ecology.wa.gov/regulations-permits/permits-certifications/stormwater-general-permits/municipal-stormwater-general-permits/municipal-stormwater-permit-reissuance.

Washington State Department of Ecology. 2023. “Standard Operating Procedure (SOP): Extraction and Analysis of 6PPD-Quinone (Mel730136, Version 1.2).” June 3.

Washington State Department of Ecology. 2023. 6PPD Alternatives Assessment Hazard Criteria . Nos. 23-04–036. https://apps.ecology.wa.gov/publications/SummaryPages/2304036.html.

Washington State Department of Ecology. 2023. 6PPD Alternatives Assessment Hazard Criteria . Nos. 23-04–036. https://apps.ecology.wa.gov/publications/documents/2304036.pdf.

Washington State Department of Ecology. 2024. Safer Products for Washington 2024 Report . Seattle, Washington. https://ecology.wa.gov/waste-toxics/reducing-toxic-chemicals/washingtons-toxics-in-products-laws/safer-products.

Weyrauch, Steffen, Bettina Seiwert, Milena Voll, Stephan Wagner, and Thorsten Reemtsma. 2023. “Accelerated Aging of Tire and Road Wear Particles by Elevated Temperature, Artificial Sunlight and Mechanical Stress — A Laboratory Study on Particle Properties, Extractables and Leachables.” Science of the Total Environment 904 (December): 166679. https://doi.org/10.1016/j.scitotenv.2023.166679.

Woudneh, Million. 2023. “Best Practices in the Analysis of 6PPD-Quinone.” ITRC Tire Anti-Degradants 6PPD Team Meeting, May 16.

Wu, Jiabin, Guodong Cao, Feng Zhang, and Zongwei Cai. 2023. “A New Toxicity Mechanism of N- (1,3-Dimethylbutyl)- N′ -Phenyl- p- Phenylenediamine Quinone: Formation of DNA Adducts in Mammalian Cells and Aqueous Organisms.” Science of the Total Environment 866: 161373. https://doi.org/10.1016/j.scitotenv.2022.161373.

Wu, Yan, Marta Venier, and Ronald A. Hites. 2020. “Broad Exposure of the North American Environment to Phenolic and Amino Antioxidants and to Ultraviolet Filters.” Environmental Science & Technology 54 (15): 9345–55. https://doi.org/10.1021/acs.est.0c04114.

Xu, Qiao, Gang Li, Li Fang, et al. 2023. “Enhanced Formation of 6PPD-Q during the Aging of Tire Wear Particles in Anaerobic Flooded Soils: The Role of Iron Reduction and Environmentally Persistent Free Radicals.” Environmental Science & Technology , ahead of print, March 29. https://doi.org/10.1021/acs.est.2c08672.

Xu, Qiao, Wei Wu, Zufei Xiao, et al. 2023. “Responses of Soil and Collembolan ( Folsomia candida ) Gut Microbiomes to 6PPD-Q Pollution.” Science of the Total Environment 900 (November): 165810. https://doi.org/10.1016/j.scitotenv.2023.165810.

Zeng, Lixi, Yi Li, Yuxin Sun, Liang-Ying Liu, Mingjie Shen, and Bibai Du. 2023. “Widespread Occurrence and Transport of p -Phenylenediamines and Their Quinones in Sediments across Urban Rivers, Estuaries, Coasts, and Deep-Sea Regions.” Environmental Science & Technology , January 31, acs.est.2c07652. https://doi.org/10.1021/acs.est.2c07652.

Zhang, Hai-Yan, Zheng Huang, Yue-Hong Liu, et al. 2023. “Occurrence and Risks of 23 Tire Additives and Their Transformation Products in an Urban Water System.” Environment International 171 (January): 107715. https://doi.org/10.1016/j.envint.2022.107715.

Zhang, Jing, Guodong Cao, Wei Wang, et al. 2024. “Stable Isotope-Assisted Mass Spectrometry Reveals in Vivo Distribution, Metabolism, and Excretion of Tire Rubber-Derived 6PPD-Quinone in Mice.” Science of the Total Environment 912 (February): 169291. https://doi.org/10.1016/j.scitotenv.2023.169291.

Zhang, Qijun, Tiange Fang, Zhengyu Men, et al. 2024. “Direct Measurement of Brake and Tire Wear Particles Based on Real-World Driving Conditions.” Science of the Total Environment 906: 167764. https://doi.org/10.1016/j.scitotenv.2023.167764.

Zhang, Ruiling, Shizhen Zhao, Xin Liu, et al. 2023. “Aquatic Environmental Fates and Risks of Benzotriazoles, Benzothiazoles, and p- Phenylenediamines in a Catchment Providing Water to a Megacity of China.” Environmental Research 216 (January): 114721. https://doi.org/10.1016/j.envres.2022.114721.

Zhang, Shu-Yun, Xiufeng Gan, Baoguo Shen, et al. 2023. “6PPD and Its Metabolite 6PPDQ Induce Different Developmental Toxicities and Phenotypes in Embryonic Zebrafish.” Journal of Hazardous Materials 455 (August): 131601. https://doi.org/10.1016/j.jhazmat.2023.131601.

Zhang, Yanhao, Caihong Xu, Wenfen Zhang, et al. 2022. “ p ‑Phenylenediamine Antioxidants in PM _2.5 : The Underestimated Urban Air Pollutants.” Environmental Science & Technology 56 (11): 6914–21. https://doi.org/https://doi.org/10.1021/acs.est.1c04500.

Zhang, Ying-Jie, Ting-Ting Xu, Dong-Min Ye, Ze-Zhao Lin, Fei Wang, and Ying Guo. 2022. “Widespread N ‑(1,3-Dimethylbutyl)‑ N′ ‑phenyl‑ p ‑phenylenediamine Quinone in Size-Fractioned Atmospheric Particles and Dust of Different Indoor Environments.” Environmental Science & Technology Letters 9 (5): 420–25. https://doi.org/https://doi.org/10.1021/acs.estlett.2c00193.

Zhang, Zhuxia, Xijin Xu, Ziyi Qian, et al. 2024. “Association between 6PPD-Quinone Exposure and BMI, Influenza, and Diarrhea in Children.” Environmental Research 247: 118201. https://doi.org/10.1016/j.envres.2024.118201.

Zhao, Feng, Jingzhi Yao, Xinyu Liu, et al. 2024. “Occurrence and Oxidation Kinetics of Antioxidant p -Phenylenediamines and Their Quinones in Recycled Rubber Particles from Artificial Turf.” Environmental Science & Technology Letters 11 (4): 335–41. https://doi.org/10.1021/acs.estlett.3c00948.

Zhao, Haoqi Nina, Sydney P. Thomas, Mark J. Zylka, Pieter C. Dorrestein, and Wenxin Hu. 2023. “Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways.” Environmental Science & Technology 57 (36): 13429–38. https://doi.org/10.1021/acs.est.3c05026.

Zhao, Haoqi Nina, Ximin Hu, Melissa Gonzalez, et al. 2023. “Screening P-Phenylenediamine Antioxidants, Their Transformation Products, and Industrial Chemical Additives in Crumb Rubber and Elastomeric Consumer Products.” Environmental Science & Technology , ahead of print, February 9. https://doi.org/10.1021/acs.est.2c07014.

Zhao, Haoqi Nina, Ximin Hu, Zhenyu Tian, et al. 2023. “Transformation Products of Tire Rubber Antioxidant 6PPD in Heterogeneous Gas-Phase Ozonation: Identification and Environmental Occurrence.” Environmental Science & Technology 57 (14): 5621–32. https://doi.org/10.1021/acs.est.2c08690.

Zhou, Yangjian, Lacuo Yixi, Qingqing Kong, et al. 2023. “Sunlight-Induced Transformation of Tire Rubber Antioxidant N -(1,3-Dimethylbutyl)- N′ -Phenyl- p- Phenylenediamine (6PPD) to 6PPD-Quinone in Water.” Environmental Science & Technology Letters 10 (9): 798–803. https://doi.org/10.1021/acs.estlett.3c00499.

Zhu, Jianqiang, Ruyue Guo, Fangfang Ren, Shengtao Jiang, and Hangbiao Jin. 2024. “Occurrence and Partitioning of p -Phenylenediamine Antioxidants and Their Quinone Derivatives in Water and Sediment.” Science of the Total Environment 914 (March): 170046. https://doi.org/10.1016/j.scitotenv.2024.170046.

Zhu, Jianqiang, Ruyue Guo, Shengtao Jiang, Pengfei Wu, and Hangbiao Jin. 2024. “Occurrence of p -Phenylenediamine Antioxidants (PPDs) and PPDs-Derived Quinones in Indoor Dust.” Science of the Total Environment 912: 169325. https://doi.org/10.1016/j.scitotenv.2023.169325.

Ziajahromi, Shima, Hsuan-Cheng Lu, Darren Drapper, Andy Hornbuckle, and Frederic D. L. Leusch. 2023. “Microplastics and Tire Wear Particles in Urban Stormwater: Abundance, Characteristics, and Potential Mitigation Strategies.” Environmental Science & Technology 57 (34): 12829–37. https://doi.org/10.1021/acs.est.3c03949.

Ziontz, Jacob. n.d. “Far-Reaching Rights: An Era of Innovation in Treaty Law in Washington State That Impacted the Rights of Aboriginal Peoples Worldwide.” Accessed July 15, 2024. https://www.historylink.org/File/10085.