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6PPD & 6PPD-quinone

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1 Introduction
1 Introduction
1.1 Summary: What Is 6PPD-q and What Is the Concern?
1.2 Transport Pathways: How Do 6PPD and 6PPD-q Get into the Environment?
1.3 What and Who Are Affected?
1.4 How Do We Identify and Measure 6PPD-q?
1.5 After We Find It, How Can We Mitigate It? What Else Can We Do?
1.6 What We Don’t Know: Knowledge and Research Gaps
1.7 Governance
1.8 Steps for Addressing 6PPD-q
2 Effects Characterization and Toxicity 
Section 2 Tables
2 Effects Characterization and Toxicity
2.1 Introduction
2.2 Environmental Toxicology
2.3 Potential for Bioaccumulation and Adduct Formation
2.4 Human Health and Toxicology
2.5 Biomonitoring for 6PPD and 6PPD-q
2.6 Potential Populations of Concern
3 Chemical Properties
3 Chemical Properties
3.1 Solubility
3.2 Half-life
3.3 Transformation Products and Processes
3.4 Volatility
3.5 Biological Uptake
3.6 Biodegradation
4 Occurrence, Fate, Transport, and Exposure Pathways 
Section 4 Tables
4 Occurrence, Fate, Transport, and Exposure Pathways
4.1 Water
4.2 Soil
4.3 Sediment
4.4 Air
4.5 Potential Food Sources and Human Consumption of 6PPD and 6PPD-q
4.6 Consumer Products
5 Measuring, Mapping, and Modeling
Section 5 Tables
5 Measuring, Mapping, and Modeling
5.1 Field Methods
5.2 Laboratory Methods
5.3 Mapping and Modeling 6PPD-q and Potentially Vulnerable Ecosystems
6 Mitigation Measures and Solutions
6 Mitigation Measures and Solutions
6.1 Introduction
6.2 Tire Alternatives and Innovation
6.3 Mitigation Practices
6.4 Remediation
7 Policies, Regulations, and Laws
7 Policies, Regulations, and Laws
7.1 Tribal Treaty Rights
7.2 Toxic Substances Control Act (TSCA)
7.3 Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA)
7.4 Resource Conservation and Recovery Act (RCRA)
7.5 Endangered Species Act (ESA)
7.6 Magnuson-Stevens Fishery Conservation and Management Act (MSA)
7.7 Safe Drinking Water Act (SDWA)
7.8 Clean Water Act (CWA)
8 Information Gaps and Research Needs
8 Information Gaps and Research Needs
8.1 Effects Characterization and Toxicity
8.2 Occurrence, Fate, Transport, and Exposure to 6PPD and 6PPD-q
8.3 How Effective Are the Proposed Solutions?
8.4 Current Research
9 References
Focus Sheet
Acronyms
Glossary
Acknowledgments
Team Contacts
Document Feedback

 

6PPD & 6PPD-quinone
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Acronyms

α-syn PFF alpha-synuclein preformed fibrils
µg/g micrograms per gram
µg/kg micrograms per kilogram
μL microliter
µg/L micrograms per liter
µg/m3 micrograms per cubic meter
μg/mL micrograms per milliliter
µm micrometer
µM micromolar
4-ADPA 4-aminodiphenylamine; CAS: 101-54-2
4-HDPA 4-hydroxydiphenylamine; CAS: 122-37-2
6PPD N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine; CAS: 793-24-8
6PPD‑q 6PPD‑quinone; CAS: 2754428-18-5
AA alternatives assessment
ACN acetonitrile; CAS: 75-05-8
ADME absorption, distribution, metabolism, and excretion
ALP alkaline phosphatase
ATP adenosine triphosphate
ALT alanine aminotransferase
ARAR applicable or relevant and appropriate requirements
ASE accelerated solvent extractor
AST aspartate aminotransferase
BAF bioaccumulation factor
BCFs bioconcentration factors
BEH bridged ethyl-siloxane/silica hybrid
B-IBI Benthic Index of Biotic Integrity
BMC Brake Manufacturers Council
BMP best management practice
cc cubic centimeter
CEC contaminants of emerging concern
CERCLA Comprehensive Environmental Response, Compensation, and Liability Act
CFR Code of Federal Regulations
cm centimeter
CMTT cryo-milled tire tread
CP-MIMS condensed phase membrane introduction mass spectrometry
CSF cerebral spinal fluid
CWA Clean Water Act
DAPD diaryl-p-phenylene diamine; CAS: 68953-84-4
DCM dichloromethane; CAS: 75-09-2
dMRM dynamic multiple reaction monitoring mode
DNA deoxyribonucleic acid
DPPD N,N’-diphenyl-1,4-phenylenediamine; CAS: 74-31-7
DQOs data quality objectives
DTSC (California) Department of Toxic Substances Control
DWTP drinking water treatment plant
EC10 10% effect concentration
EC50 50% effect concentration
ECHA European Chemicals Agency
EDTA ethylenediaminetetraacetic acid; CAS: 60-00-4
EFH essential fish habitat
EIS extracted internal standard
Eco-SSLs ecological soil screening levels
ESA Endangered Species Act
ESI electrospray ionization
FAF5 Freight Analysis Framework version 5
GAPS Global Atmospheric Passive Sampling
GAPS-Megacities Global Atmospheric Passive Sampling Network
GC gas chromatography
GC/MS gas chromatography / mass spectrometry
GC-QTOF-HRMS gas chromatography–quadrupole time-of-flight–high-resolution mass spectrometry
GFF glass fiber filter
GIS geographic information system
g/L grams per liter
HDPE high-density polyethylene
Herrera Herrera Environmental Consulting
HESI heated electrospray ionization mode
HLB hydrophilic-lipophilic-balanced
HPBSM high-performance bioretention soil mixes
HPLC high-performance liquid chromatography
HRGC/HRMS high-resolution gas chromatography / high-resolution mass spectrometry
HRMS high-resolution mass spectrometry
HSAID hot-surface induced desolvation
HSS T3 high-strength silica, trifunctionally bonded
HUC hydraulic unit code
ICP/MS inductively coupled plasma / mass spectrometry
ID inner diameter
IDL instrument detection limit
ILC50 internal median lethal concentration 50%
IPPD phenyl-p-phenylenediamine; CAS: 101-72-4
IQL instrument quantification limit
ISTD internal standards
ITRC Interstate Technology and Regulatory Council
KCEL King County Environmental Laboratory
LC liquid chromatography
LC10 lethal concentration 10%
LC50 lethal concentration 50%
LC-HRMS liquid chromatography / high-resolution mass spectrometry
LC-MS liquid chromatography / mass spectrometry
LC-MS/MS liquid chromatography / tandem mass spectrometry
LC-QTOF-HRMS liquid chromatography / quadrupole time-of-flight / high-resolution mass spectrometry
LD50 median lethal dose
LOAEL lowest observed adverse effect level
LOEC lowest observed effect concentration
LOEL lowest observed effect level
LOD limit of detection
LOQ limit of quantitation
LTCP long-term control plan
LVSPE large-volume solid-phase extraction
m meters
m3 cubic meter
MCLs maximum contaminant levels
MDL method detection limit
MEMA Motor & Equipment Manufacturers Association
MeOH methanol; CAS: 67-56-1
mg milligram
mg/kg milligrams per kilogram
mg/kg-bw milligrams per kilogram of body weight
mg/L milligrams per liter
mg/m3 milligrams per cubic meter
mL milliliter
ML minimum level of quantification
mm millimeter
mM millimolar
mmol millimol
mmol/L millimole per liter
mol/L mole per liter
MQL method quantification limit
MRL method reporting limit
MRM multiple reaction monitoring mode
MS mass spectrometry
MS2 tandem mass spectrometry
MS4 municipal separate storm sewer systems
MSA Magnuson-Stevens Fishery Conservation and Management Act
MS/ddMS2 MS/ddMS2=mass spectrometry / data dependent tandem mass spectrometry
NAS (USGS) Nonindigenous Aquatic Species
ND nondetect
ng/g nanograms per gram
ng/kg-bw/day nanograms per kilogram of body weight per day
ng/L nanograms per liter
ng/mg dw nanogram per milligram dry weight
ng/mL nanograms per milliliter
nM nanometer
NOAA National Oceanic and Atmospheric Administration
NOAEL no observed adverse effect level
NOEC no observed effect level concentration
NOEL no observed effect level
NPDES National Pollutant Discharge Elimination System
NREL National Renewable Energy Laboratory
NWIFC Northwest Indian Fisheries Commission
OECD Organisation for Economic Co-Operation and Development
OW (USEPA) Office of Water
PAH polynuclear aromatic hydrocarbon
PAS passive air sampler
PD Parkinson’s disease
PDMS polydimethylsiloxane
PE polyethylene
PET polyethylene terephthalate
PFF preformed fibrils
PPD para-phenylenediamine; CAS: 106-50-3
pg picogram
pg/m3 picograms per cubic meter
PM0.1 ultrafine particulate matter, 0.1 micrometers or less in diameter
PM2.5 fine particulate matter 2.5 micrometers or less in diameter
PM10 coarse particulate matter, between 2.5 micrometers and 10 micrometers in diameter
POCIS Polar Organic Chemical Integrative Sampler
POM polyoxymethylene
PPDs para-phenylenediamines, class of
PPD‑q para-phenylenediamines-quinone
PPE personal protective equipment
ppm parts per million
PRM parallel reaction monitoring
PTFE polytetrafluoroethylene
PUF polyurethane foam
pyro-GC/MS pyrolysis–gas chromatography / mass spectrometry
QTOF quadrupole time-of-flight
QTOF/MS quadrupole time-of-flight / mass spectrometry
QuEChERS A solid-phase extraction method: Quick, Easy, Cheap, Effective, Rugged, and Safe
RAC rubberized asphalt concrete
RARα retinoic acid receptor α
RCRA Resource Conservation and Recovery Act
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
RI/FS remedial investigation / feasibility study
RMA rubber-modified asphalt
RNA ribonucleic acid
RXRα retinoid X receptor α
SCM stormwater control measure
SD standard deviation
SDWA Safe Drinking Water Act
SIP state implementation plan
SOP standard operating procedure
SPE solid-phase extraction
SRM selected reaction monitoring
SSTD surrogate standard
SWIFD Statewide Integrated Fish Distribution
TAPE Technology Assessment Protocol–Ecology
TCI Tokyo Chemical Industry
TD thermal desorption
TK toxicokinetics
TMDL Total Maximum Daily Load
TNC The Nature Conservancy
TRC Toronto Research Chemical
TRWP tire- and road-wear particles
TSCA Toxic Substances Control Act
TWA time-weighted average
TWC tire-wear contaminants
TWP tire-wear particles
UHPLC ultra-high–performance liquid chromatography
UPLC ultra-performance liquid chromatography
UPLC-QTOF-MS/MS ultra-performance liquid chromatography–quadrupole time-of-flight–tandem mass spectrometry
UPLC-TOF-MS ultra-performance liquid chromatography–time-of-flight–mass spectrometry
URMS urban runoff mortality syndrome
USDA U.S. Department of Agriculture
USEPA U.S. Environmental Protection Agency
USFWS U.S. Fish and Wildlife Service
USGS U.S. Geological Survey
USTMA U.S. Tire Manufacturers Association
VELMA Visualizing Ecosystem Land Management Assessments
v/v volume per volume
WA Ecology Washington State Department of Ecology
WDFW Washington (State) Department of Fish and Wildlife
WDOC Washington State Department of Commerce
WET whole effluent toxicity
WaTech Solutions Washington (State) Technology Solutions
WQS water quality standards
WSDOT Washington State Department of Transportation
WSU Washington State University
WWTP wastewater treatment plants

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6PPD & 6PPD-quinone

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