Acronyms
| α-syn PFF | alpha-synuclein preformed fibrils |
| µg/g | micrograms per gram |
| µg/kg | micrograms per kilogram |
| μL | microliter |
| µg/L | micrograms per liter |
| µg/m3 | micrograms per cubic meter |
| μg/mL | micrograms per milliliter |
| µm | micrometer |
| µM | micromolar |
| 4-ADPA | 4-aminodiphenylamine; CAS: 101-54-2 |
| 4-HDPA | 4-hydroxydiphenylamine; CAS: 122-37-2 |
| 6PPD | N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine; CAS: 793-24-8 |
| 6PPD‑q | 6PPD‑quinone; CAS: 2754428-18-5 |
| AA | alternatives assessment |
| ACN | acetonitrile; CAS: 75-05-8 |
| ADME | absorption, distribution, metabolism, and excretion |
| ALP | alkaline phosphatase |
| ATP | adenosine triphosphate |
| ALT | alanine aminotransferase |
| ARAR | applicable or relevant and appropriate requirements |
| ASE | accelerated solvent extractor |
| AST | aspartate aminotransferase |
| BAF | bioaccumulation factor |
| BCFs | bioconcentration factors |
| BEH | bridged ethyl-siloxane/silica hybrid |
| B-IBI | Benthic Index of Biotic Integrity |
| BMC | Brake Manufacturers Council |
| BMP | best management practice |
| cc | cubic centimeter |
| CEC | contaminants of emerging concern |
| CERCLA | Comprehensive Environmental Response, Compensation, and Liability Act |
| CFR | Code of Federal Regulations |
| cm | centimeter |
| CMTT | cryo-milled tire tread |
| CP-MIMS | condensed phase membrane introduction mass spectrometry |
| CSF | cerebral spinal fluid |
| CWA | Clean Water Act |
| DAPD | diaryl-p-phenylene diamine; CAS: 68953-84-4 |
| DCM | dichloromethane; CAS: 75-09-2 |
| dMRM | dynamic multiple reaction monitoring mode |
| DNA | deoxyribonucleic acid |
| DPPD | N,N’-diphenyl-1,4-phenylenediamine; CAS: 74-31-7 |
| DQOs | data quality objectives |
| DTSC | (California) Department of Toxic Substances Control |
| DWTP | drinking water treatment plant |
| EC10 | 10% effect concentration |
| EC50 | 50% effect concentration |
| ECHA | European Chemicals Agency |
| EDTA | ethylenediaminetetraacetic acid; CAS: 60-00-4 |
| EFH | essential fish habitat |
| EIS | extracted internal standard |
| Eco-SSLs | ecological soil screening levels |
| ESA | Endangered Species Act |
| ESI | electrospray ionization |
| FAF5 | Freight Analysis Framework version 5 |
| GAPS | Global Atmospheric Passive Sampling |
| GAPS-Megacities | Global Atmospheric Passive Sampling Network |
| GC | gas chromatography |
| GC/MS | gas chromatography / mass spectrometry |
| GC-QTOF-HRMS | gas chromatography–quadrupole time-of-flight–high-resolution mass spectrometry |
| GFF | glass fiber filter |
| GIS | geographic information system |
| g/L | grams per liter |
| HDPE | high-density polyethylene |
| Herrera | Herrera Environmental Consulting |
| HESI | heated electrospray ionization mode |
| HLB | hydrophilic-lipophilic-balanced |
| HPBSM | high-performance bioretention soil mixes |
| HPLC | high-performance liquid chromatography |
| HRGC/HRMS | high-resolution gas chromatography / high-resolution mass spectrometry |
| HRMS | high-resolution mass spectrometry |
| HSAID | hot-surface induced desolvation |
| HSS T3 | high-strength silica, trifunctionally bonded |
| HUC | hydraulic unit code |
| ICP/MS | inductively coupled plasma / mass spectrometry |
| ID | inner diameter |
| IDL | instrument detection limit |
| ILC50 | internal median lethal concentration 50% |
| IPPD | phenyl-p-phenylenediamine; CAS: 101-72-4 |
| IQL | instrument quantification limit |
| ISTD | internal standards |
| ITRC | Interstate Technology and Regulatory Council |
| KCEL | King County Environmental Laboratory |
| LC | liquid chromatography |
| LC10 | lethal concentration 10% |
| LC50 | lethal concentration 50% |
| LC-HRMS | liquid chromatography / high-resolution mass spectrometry |
| LC-MS | liquid chromatography / mass spectrometry |
| LC-MS/MS | liquid chromatography / tandem mass spectrometry |
| LC-QTOF-HRMS | liquid chromatography / quadrupole time-of-flight / high-resolution mass spectrometry |
| LD50 | median lethal dose |
| LOAEL | lowest observed adverse effect level |
| LOEC | lowest observed effect concentration |
| LOEL | lowest observed effect level |
| LOD | limit of detection |
| LOQ | limit of quantitation |
| LTCP | long-term control plan |
| LVSPE | large-volume solid-phase extraction |
| m | meters |
| m3 | cubic meter |
| MCLs | maximum contaminant levels |
| MDL | method detection limit |
| MEMA | Motor & Equipment Manufacturers Association |
| MeOH | methanol; CAS: 67-56-1 |
| mg | milligram |
| mg/kg | milligrams per kilogram |
| mg/kg-bw | milligrams per kilogram of body weight |
| mg/L | milligrams per liter |
| mg/m3 | milligrams per cubic meter |
| mL | milliliter |
| ML | minimum level of quantification |
| mm | millimeter |
| mM | millimolar |
| mmol | millimol |
| mmol/L | millimole per liter |
| mol/L | mole per liter |
| MQL | method quantification limit |
| MRL | method reporting limit |
| MRM | multiple reaction monitoring mode |
| MS | mass spectrometry |
| MS2 | tandem mass spectrometry |
| MS4 | municipal separate storm sewer systems |
| MSA | Magnuson-Stevens Fishery Conservation and Management Act |
| MS/ddMS2 | MS/ddMS2=mass spectrometry / data dependent tandem mass spectrometry |
| NAS | (USGS) Nonindigenous Aquatic Species |
| ND | nondetect |
| ng/g | nanograms per gram |
| ng/kg-bw/day | nanograms per kilogram of body weight per day |
| ng/L | nanograms per liter |
| ng/mg dw | nanogram per milligram dry weight |
| ng/mL | nanograms per milliliter |
| nM | nanometer |
| NOAA | National Oceanic and Atmospheric Administration |
| NOAEL | no observed adverse effect level |
| NOEC | no observed effect level concentration |
| NOEL | no observed effect level |
| NPDES | National Pollutant Discharge Elimination System |
| NREL | National Renewable Energy Laboratory |
| NWIFC | Northwest Indian Fisheries Commission |
| OECD | Organisation for Economic Co-Operation and Development |
| OW | (USEPA) Office of Water |
| PAH | polynuclear aromatic hydrocarbon |
| PAS | passive air sampler |
| PD | Parkinson’s disease |
| PDMS | polydimethylsiloxane |
| PE | polyethylene |
| PET | polyethylene terephthalate |
| PFF | preformed fibrils |
| PPD | para-phenylenediamine; CAS: 106-50-3 |
| pg | picogram |
| pg/m3 | picograms per cubic meter |
| PM0.1 | ultrafine particulate matter, 0.1 micrometers or less in diameter |
| PM2.5 | fine particulate matter 2.5 micrometers or less in diameter |
| PM10 | coarse particulate matter, between 2.5 micrometers and 10 micrometers in diameter |
| POCIS | Polar Organic Chemical Integrative Sampler |
| POM | polyoxymethylene |
| PPDs | para-phenylenediamines, class of |
| PPD‑q | para-phenylenediamines-quinone |
| PPE | personal protective equipment |
| ppm | parts per million |
| PRM | parallel reaction monitoring |
| PTFE | polytetrafluoroethylene |
| PUF | polyurethane foam |
| pyro-GC/MS | pyrolysis–gas chromatography / mass spectrometry |
| QTOF | quadrupole time-of-flight |
| QTOF/MS | quadrupole time-of-flight / mass spectrometry |
| QuEChERS | A solid-phase extraction method: Quick, Easy, Cheap, Effective, Rugged, and Safe |
| RAC | rubberized asphalt concrete |
| RARα | retinoic acid receptor α |
| RCRA | Resource Conservation and Recovery Act |
| REACH | Registration, Evaluation, Authorisation and Restriction of Chemicals |
| RI/FS | remedial investigation / feasibility study |
| RMA | rubber-modified asphalt |
| RNA | ribonucleic acid |
| RXRα | retinoid X receptor α |
| SCM | stormwater control measure |
| SD | standard deviation |
| SDWA | Safe Drinking Water Act |
| SIP | state implementation plan |
| SOP | standard operating procedure |
| SPE | solid-phase extraction |
| SRM | selected reaction monitoring |
| SSTD | surrogate standard |
| SWIFD | Statewide Integrated Fish Distribution |
| TAPE | Technology Assessment Protocol–Ecology |
| TCI | Tokyo Chemical Industry |
| TD | thermal desorption |
| TK | toxicokinetics |
| TMDL | Total Maximum Daily Load |
| TNC | The Nature Conservancy |
| TRC | Toronto Research Chemical |
| TRWP | tire- and road-wear particles |
| TSCA | Toxic Substances Control Act |
| TWA | time-weighted average |
| TWC | tire-wear contaminants |
| TWP | tire-wear particles |
| UHPLC | ultra-high–performance liquid chromatography |
| UPLC | ultra-performance liquid chromatography |
| UPLC-QTOF-MS/MS | ultra-performance liquid chromatography–quadrupole time-of-flight–tandem mass spectrometry |
| UPLC-TOF-MS | ultra-performance liquid chromatography–time-of-flight–mass spectrometry |
| URMS | urban runoff mortality syndrome |
| USDA | U.S. Department of Agriculture |
| USEPA | U.S. Environmental Protection Agency |
| USFWS | U.S. Fish and Wildlife Service |
| USGS | U.S. Geological Survey |
| USTMA | U.S. Tire Manufacturers Association |
| VELMA | Visualizing Ecosystem Land Management Assessments |
| v/v | volume per volume |
| WA Ecology | Washington State Department of Ecology |
| WDFW | Washington (State) Department of Fish and Wildlife |
| WDOC | Washington State Department of Commerce |
| WET | whole effluent toxicity |
| WaTech Solutions | Washington (State) Technology Solutions |
| WQS | water quality standards |
| WSDOT | Washington State Department of Transportation |
| WSU | Washington State University |
| WWTP | wastewater treatment plants |


